Document Detail

CT X-ray measurement of cerebral blood flow by stable xenon. Methodology and applications
MedLine Citation:
PMID:  1843840     Owner:  NLM     Status:  MEDLINE    
The measurement of cerebral blood flow by stable xenon computerized tomography is a tridimensional method that offers an excellent spatial resolution. The quantitative estimation of the cerebral blood flow is based on Fick's principle, transformed by Kety and Schmidt, using stable xenon as indicator, which is an inert and freely diffusible gas. The limitations of this method are related to the necessity for the patient to remain completely immobile during the examination, the low signal/noise ratio and the impossibility of measuring cerebral metabolism. By contrast, this method represents a real advantage in the diagnosis and prognosis of cerebral pathology: it allows the acquisition of a precise cartography of superficial and deep regional blood flows; it can reveal zones under the functional perfusion threshold thank to its capacity to measure very low blood flows; it allows the obtention of additional information in pathologies of tumoral, ischemic or degenerative origin by measuring the partition coefficient. Moreover, this technique is reliable, non invasive and reproducible. Advantages of such measurement are illustrated in revealing epileptic foci in partial seizures resistant to medical treatment, in the prognosis of cerebrovascular accidents and in the therapeutic evaluation of drugs used in animal experiments.
A M Gin; A M Bidabe; D Gense de Beaufort; J M Caille
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l'agression     Volume:  32     ISSN:  0002-1148     ISO Abbreviation:  Agressologie     Publication Date:  1991  
Date Detail:
Created Date:  1993-03-23     Completed Date:  1993-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121575     Medline TA:  Agressologie     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  353-8     Citation Subset:  IM    
Service de neuroradiologie, Centre hospitalier régional et universitaire, Bordeaux.
Vernacular Title:
Mesure tomodensitométrique du débit sanguin cérébral par xénon stable. Méthodologie et applications.
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MeSH Terms
Blood Flow Velocity*
Brain / radiography*
Brain Diseases / radiography
Cerebrovascular Circulation*
Tomography, X-Ray Computed*
Xenon / diagnostic use
Reg. No./Substance:

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