| CT tumor volume measurement in advanced non-small-cell lung cancer: Performance characteristics of an emerging clinical tool. | |
| | |
MedLine Citation:
|
PMID: 21036632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE AND OBJECTIVES: Determine inter- and intraobserver variability of computed tomography (CT) tumor volume measurements in advanced non-small-cell lung cancer (NSCLC) patients treated in a Phase II clinical trial using chest CT. MATERIALS AND METHODS: Twenty-three advanced NSCLC patients with a total of 53 measurable lung lesions enrolled in a Phase II, multicenter, open-label clinical trial of erlotinib were retrospectively studied with institutional review board approval. Two radiologists independently measured the tumor size, volume, and CT attenuation coefficient using commercially available volume analysis software. Concordance correlation coefficients (CCCs) and Bland-Altman plots were used to assess inter- and intraobserver agreement. RESULTS: High CCCs (0.949-0.990) were observed in all types of measurements for interobserver agreement. The 95% limits of agreements for volume, unidimensional, and bidimensional measurements were (-26.0%, 18.6%), (-23.1%, 24.4%), and (-34.0%, 48.6%), respectively. Volume measurement had slightly higher CCC and narrower 95% limits of agreement compared to uni- and bidimensional measurements. CCCs for intraobserver agreement were high (range, 0.946-0.996) with CCC for volume being slightly higher than CCCs of uni- and bidimensional measurements. The smaller the tumor volume was, the larger the interobserver difference of CT attenuation. Location, morphology, or adjacent atelectasis had no significant impact on inter- or intraobserver variability. CONCLUSION: CT tumor volume measurement in advanced NSCLC patients using clinical chest CT and commercially available software demonstrated high inter- and intraobserver agreement, indicating that the method may be used routinely in clinical practice. |
| | |
Authors:
|
Mizuki Nishino; Mengye Guo; David M Jackman; Pamela J DiPiro; Jeffrey T Yap; Tak K Ho; Hiroto Hatabu; Pasi A Jänne; Annick D Van den Abbeele; Bruce E Johnson |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-30 |
Journal Detail:
|
Title: Academic radiology Volume: 18 ISSN: 1878-4046 ISO Abbreviation: Acad Radiol Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-14 Completed Date: 2011-04-19 Revised Date: 2011-11-30 |
Medline Journal Info:
|
Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 54-62 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 AUR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Imaging, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Mizuki_Nishino@dfci.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung / pathology, radiography* Cone-Beam Computed Tomography / methods* Contrast Media / diagnostic use Female Humans Imaging, Three-Dimensional / methods Iohexol / analogs & derivatives, diagnostic use Lung / pathology, radiography Lung Neoplasms / pathology, radiography* Male Observer Variation Radiographic Image Enhancement / methods Retrospective Studies Tumor Burden* |
| Grant Support | |
ID/Acronym/Agency:
|
1R01CA114465-01/CA/NCI NIH HHS; 2P50CA090578-06/CA/NCI NIH HHS; 5R21 CA11627-02/CA/NCI NIH HHS; P20 CA090578-01A1/CA/NCI NIH HHS; P20 CA090578-02/CA/NCI NIH HHS; P20 CA090578-03/CA/NCI NIH HHS; P20 CA090578-04/CA/NCI NIH HHS; P20 CA090578-05/CA/NCI NIH HHS; P50 CA090578-06/CA/NCI NIH HHS; P50 CA090578-07/CA/NCI NIH HHS; P50 CA090578-08/CA/NCI NIH HHS; P50 CA090578-09/CA/NCI NIH HHS; R01 CA114465-01/CA/NCI NIH HHS; R01 CA114465-02/CA/NCI NIH HHS; R01 CA114465-03/CA/NCI NIH HHS; R01 CA114465-04/CA/NCI NIH HHS; R01 CA114465-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 66108-95-0/Iohexol; 73334-07-3/iopromide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predictors of clinical outcome in acute pulmonary embolism: Correlation of CT pulmonary angiography ...
Next Document: The role of retinal regulation of sleep in health and disease.