| CT Score and Pulmonary Function in Infants with Chronic Lung Disease of Infancy. | |
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MedLine Citation:
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PMID: 21478219 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic lung disease of Infancy (CLDI) remains a common outcome among infants born extremely premature. In older children and adults with lung disease, pulmonary function and computed tomography (CT) scores are used to follow-up respiratory disease and assess disease severity. For infants and toddlers, these outcomes have been used very infrequently and most often a dichotomous respiratory outcome (presence or absence of CLDI) is employed. We evaluated the performance of CT score and pulmonary function to differentiate infants and toddlers with CLDI from a control group. CT scans, forced expiratory flows, and pulmonary diffusing capacity were obtained in 39 CLDI and 41 Controls (4-33 months of age). CT scans were quantified using a scoring system, while pulmonary function was expressed as Z-scores. CT score outperformed pulmonary function in identifying those with CLDI. There were no significant correlations between CT score and pulmonary function. CT score had a better performance than pulmonary function; however, these outcomes may reflect differing components of the pulmonary pathophysiology of CLDI. This new information on pulmonary outcomes can assist in designing studies with these parameters. Future studies will be required to evaluate which of the outcomes can better detect improvement with therapeutic intervention and/or lung growth. |
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Authors:
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E E Sarria; R Mattiello; L Rao; M R Wanner; M E Raske; C Tiller; R Kimmel; R S Tepper |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-8 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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James Whitcomb Riley Hospital for Children, Indiana University Indianapolis, IN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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