| CT perfusion with angiography as a substitute for both conventional digital subtraction angiography and acetazolamide-challenged SPECT in the follow-up of postbypass patients. | |
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MedLine Citation:
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PMID: 20948198 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: We evaluated the clinical usefulness of CT perfusion (CTP) with angiography (CTA) as an alternative to digital subtraction angiography (DSA) and acetazolamide (ACZ)-challenged single-photon emission computed tomography (SPECT) in the follow-up evaluation of hemodynamic changes and bypass patency after bypass surgery in chronic cerebral ischemic diseases. METHODS: Thirty-five patients who underwent superficial temporal artery/middle cerebral artery bypass surgery for chronic cerebral ischemic diseases were retrospectively enrolled. We assessed the relationship between CTP parameters [cerebral blood volume, cerebral blood flow (CBF), mean transit time (MTT), affected-to-unaffected hemisphere (ATU) ratio of perfusion parameters and MTT differences between hemispheres] and SPECT parameters (regional CBF and cerebrovascular reserve) and compared the preoperative CTP parameters with the postoperative ones. For the bypass patency, we compared CTA with DSA. RESULTS: MTT showed the best correlation with CVR of SPECT (r = -0.343; p < 0.001). ATU ratio (r = -0.547; p < 0.001) and ATU differences (r = -0.592; p < 0.001) of MTT correlated well with the ATU ratio of rCBF on ACZ-challenged SPECT. Significant improvement of perfusion parameters could be demonstrated in the affected vascular territory with postoperative CTP. The CTA findings were consistent with those of DSA in 96% of the cases. The examination-related complication rate was 0, 2.8 and 8.6% for CT studies, DSA and SPECT, respectively. CONCLUSIONS: CTP performed simultaneously with CTA seems to be a safe and efficient substitute for DSA and ACZ-challenged SPECT in the follow-up evaluation after bypass surgery in patients with chronic cerebral ischemic diseases. |
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Authors:
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Jung Cheol Park; Jeong Eun Kim; Hyun-Seung Kang; Chul-Ho Sohn; Dong Soo Lee; Chang Wan Oh; Moon Hee Han |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-14 |
Journal Detail:
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Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 30 ISSN: 1421-9786 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 547-55 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Neurosurgery, Jeju National University College of Medicine, Jeju, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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