| CT and MR Imaging of the Adrenal Glands in Cortisol-secreting Tumors. | |
| | |
MedLine Citation:
|
PMID: 21868539 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Cushing's syndrome (CS), first described by the neurosurgeon Harvey Cushing in the 1930s, is the result of chronic glucocorticoid excess. In patients with adreno-corticotropic hormone (ACTH)-dependent CS, bilateral hyperplasia of the adrenal cortex occurs, while in those with ACTH-independent primary CS, either adrenocortical tumors or primary adrenal hyperplasia can be observed. Cortisol-secreting adrenocortical tumors are more frequently adenomas, while adrenal carcinoma accounts for only 5% of cases. Unfortunately, no reliable endocrinological tests are available and no specific tumor markers exist to differentiate between benign and malignant adrenal tumors, so both computed tomography (CT) and magnetic resonance (MR) imaging studies are currently required to localize and define adrenal lesions. Additional information to conventional imaging can be obtained using (18)F-fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET)/CT, while percutaneous image-guided fine-needle aspiration cytology (FNAC) in some cases has shown a high accuracy in detecting malignancy and in confirming adrenal metastases. New PET tracers with selective affinity for the adrenal tissue are still under evaluation. Multidetector CT scan, with the combination of unenhanced and dynamic scans, represents the single most accurate modality for the detection and the characterization of adrenal adenomas. In these lesions, chemical-shift MR imaging produces a typical loss of signal intensity on out-of-phase breath-hold gradient-echo images in lipid-rich adenomas. For these lesions there is no difference between CT and MR imaging, while MR chemical shift imaging is very helpful in identifying the additional small group of adenomas where intracellular lipid content is minimal. |
| | |
Authors:
|
Franco Lumachi; Paolo Marchesi; Diego Miotto; Raffaella Motta |
Related Documents
:
|
11746309 - Central pontine myelinolysis in a patient with anorexia nervosa. 1477189 - Magnetic resonance imaging of the posterior fossa in autism. 18230279 - Giant hydatid cyst in the posterior fossa of a child: a case report. 8089319 - Ataxia-telangiectasia: mr and ct findings. 9609309 - Palatal myoclonus induced by extirpation of a cerebellar astrocytoma. case report. 9371939 - Cerebral involvement in celiac disease: a serial mri study in a patient with brainstem ... 1574989 - Gd-dtpa-enhanced lesions in the brain of patients with acute optic neuritis. 9002769 - Whole body and tomographic scan with 111in-pentetreotide: preliminary data. 18534309 - Severe intracranial and intraspinal subarachnoid hemorrhage after lumbar puncture: a ra... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Anticancer research Volume: 31 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
|
Languages: eng Pagination: 2923-6 Citation Subset: IM |
Affiliation:
|
University of Padua, School of Medicine, Department of Surgical & Gastroenterological Sciences, Via Giustiniani 2, 35128 Padova, Italy. flumachi@unipd.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Panipenem Does Not Alter the Pharmacokinetics of the Active Metabolite of Irinotecan SN-38 and Inact...
Next Document: Cryotreatment against Metastatic Renal Cell Bone Tumour Reduced Multiple Lung Metastases.