| CT, MR, (18)F-FDG PET/CT, and their combined use for the assessment of mandibular invasion by squamous cell carcinomas of the oral cavity. | |
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MedLine Citation:
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PMID: 20929295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: a reliable assessment of mandibular invasion is crucial for treatment planning to obtain both radical tumor resection and good functional results. PURPOSE: to retrospectively compare the diagnostic value of three different imaging methods - computed tomography (CT), magnetic resonance (MR) imaging, (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT - and their combined use for detection of mandibular invasion by squamous cell carcinoma (SCC) of the oral cavity. MATERIAL AND METHODS: forty-six patients (39 men and 7 women; mean age, 59.4 years) suspected of having mandibular invasion by SCC of the oral cavity underwent CT, MR, and PET/CT within 2 weeks before surgery. First, each study was reviewed separately for the presence of mandibular invasion by tumors. Then, the value of combined images was assessed based on a confidence rating score for each modality assigned by observers. These results were verified with histopathologic findings. RESULTS: HIstopathologic examination revealed mandibular invasion in 12 of 46 SCCs. The sensitivity, specificity, and accuracy were 41.7%, 100%, and 84.8% for CT; 58.3%, 97.1%, and 87.0% for MR; and 58.3%, 97.1%, and 87.0% for PET/CT, respectively. The comparison of these modalities showed no statistically significant difference among them (P > 0.05). The combination of CT, MR, and PET/CT improved sensitivity (83.3%), without loss of specificity (100%) and accuracy (95.7%), although the difference failed to reach statistical significance (P > 0.05). CONCLUSION: the combined analysis of CT, MR, and PET/CT can improve sensitivity in the detection of mandibular invasion by SCC of the oral cavity. |
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Authors:
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Dong Hyeon Gu; Dae Young Yoon; Chan Hee Park; Suk Ki Chang; Kyoung Ja Lim; Young Lan Seo; Eun Joo Yun; Chul Soon Choi; Sang Hoon Bae |
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Publication Detail:
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Type: Journal Article Date: 2010-10-07 |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 51 ISSN: 1600-0455 ISO Abbreviation: Acta Radiol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: England |
Other Details:
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Languages: eng Pagination: 1111-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, Kangdong Seong-Sim Hospital, Hallym University College of Medicine, Seoul, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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diagnosis* Contrast Media / diagnostic use Female Fluorodeoxyglucose F18 / diagnostic use* Gadolinium DTPA / diagnostic use Humans Image Enhancement / methods Iohexol / diagnostic use Magnetic Resonance Imaging / methods* Male Mandible / pathology, radiography, radionuclide imaging Mandibular Neoplasms / diagnosis*, pathology Middle Aged Mouth Neoplasms / diagnosis*, pathology Neoplasm Invasiveness / diagnosis, pathology Observer Variation Positron-Emission Tomography / methods Radiopharmaceuticals / diagnostic use Reproducibility of Results Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Radiopharmaceuticals; 122795-43-1/gadodiamide; 63503-12-8/Fluorodeoxyglucose F18; 66108-95-0/Iohexol; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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