| CT angiographic source images: flow- or volume-weighted? | |
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MedLine Citation:
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PMID: 21051518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: CTA-SI have been previously reported to correlate with CBV. We hypothesized that CTA-SI performed by modern multisection CT scanners are CBF-, not CBV-weighted. MATERIALS AND METHODS: Sixty-four consecutive patients with anterior circulation stroke symptoms were selected from a stroke data base between June 2007 and January 2009. Two independent blinded readers calculated defect volumes of CTA-SI and PCCT, CBF, and CBV images. Spearman correlation of lesion volumes was performed. Linear regression and residual analysis demonstrated factors associated with outliers for CTA or PCCT for CBF and CBV volumes. RESULTS: We found a strong positive correlation between CTA with CBF (r = 0.89, P < .0001) and between PCCT and CBV (r = 0.79, P < .0001). CTA to CBV (r = 0.5, P < .0001) and PCCT to CBF (r = 0.52, P < .0001) correlations were weaker. Positive CTA outliers had lower ASPECTS (P = .01), larger baseline CTA (149 ± 46 cm(3) versus 83 ± 32 cm(3); P = .002, respectively), and final infarct (190 ± 100 cm(3) versus 80 ± 50 cm(3); P = .09, respectively) volumes than nonoutliers. No baseline features were significantly related to PCCT outliers. There was no difference in the vessel occlusion sites for positive or negative outliers for CTA or PCCT (P = .55 and P = 1.00, respectively). CONCLUSIONS: Our results indicate that CTA-SI are CBF- rather than CBV-weighted. |
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Authors:
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M Sharma; A J Fox; S Symons; A Jairath; R I Aviv |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-11-04 |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 32 ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-18 Completed Date: 2011-06-07 Revised Date: 2012-05-18 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
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Languages: eng Pagination: 359-64 Citation Subset: IM |
Affiliation:
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Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Volume
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physiology* Cerebral Angiography / methods* Cerebrovascular Circulation / physiology* Databases, Factual Humans Infarction, Anterior Cerebral Artery / physiopathology, radiography* Linear Models Tomography, X-Ray Computed / methods* |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 2012 Apr;33(4):E61; author reply E62
[PMID:
22322617
]
AJNR Am J Neuroradiol. 2011 May;32(5):E93; author reply E94 [PMID: 21474630 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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