| CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: two case reports. | |
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MedLine Citation:
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PMID: 19747766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report two cases of superficial siderosis (SS) of the central nervous system (CNS), which is caused by chronic haemorrhaging into the subarachnoid space with haemosiderin deposition in the superficial portion of the CNS. Patient 1 had fluid collection in the spinal canal, which was reported as the source of the chronic bleeding. Patient 2 was bleeding from thickened dura at the level of the sacral vertebrae. Both of the patients had xanthochromic cerebrospinal fluid. We surgically repaired the sources of bleeding. Subsequently the cerebrospinal fluid (CSF) cleared and their symptoms were not aggravated for about 1 year. We measured several CSF markers of SS before and after surgery. Total tau protein (CSF-t-tau), phosphorylated tau protein (CSF-p-tau), iron (CSF-iron) and ferritin (CSF-ferritin) in the CSF were highly elevated at diagnosis. After surgery, the levels of CSF-t-tau and CSF-p-tau were markedly reduced while CSF-iron and CSF-ferritin had not decreased. It is suggested that CSF-t-tau and CSF-p-tau reflected the neural damage in SS and were useful to evaluate the effectiveness of SS therapies. |
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Authors:
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Tokuhei Ikeda; Daisuke Noto; Moeko Noguchi-Shinohara; Kenjiro Ono; Kazuya Takahashi; Chiho Ishida; Mitsuhiro Yoshita; Masahito Kawaguchi; Norio Kawahara; Kazuo Iwasa; Katsurou Tomita; Masahito Yamada |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-09-11 |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 112 ISSN: 1872-6968 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 62-4 Citation Subset: IM |
Copyright Information:
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2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. tokuhei@med.kanazawa-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / cerebrospinal fluid* Central Nervous System Diseases / cerebrospinal fluid*, pathology, therapy* Dysarthria / etiology Female Ferritins / cerebrospinal fluid Gait Disorders, Neurologic / etiology Hearing Disorders / etiology Humans Iron / cerebrospinal fluid Magnetic Resonance Imaging Siderosis / cerebrospinal fluid*, pathology, therapy* Spinal Cord / pathology tau Proteins / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/tau Proteins; 7439-89-6/Iron; 9007-73-2/Ferritins |
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