| CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. | |
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MedLine Citation:
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PMID: 1691169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A neuroanatomical central nervous system (CNS) mechanism for the expression of emotions and behaviors in animals has now been proposed for over 50 years. More specifically, alterations in CNS serotonin associated with aggressive behavior in certain animal models have been among the most frequent, reliable, and replicable findings. Because alterations in CNS monoamines, i.e., catechols and indols, have been related to hypotheses for affective disorders and associated with both suicidal and aggressive behaviors, human clinical implications have emerged. The original studies, which reported an association between low cerebrospinal fluid 5-hydroxyindole-acetic acid concentration and impulsive, destructive behaviors, particularly where aggression and violence are involved, have now been replicated rather consistently in a number of countries and cultures. |
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Authors:
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G L Brown; M I Linnoila |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 51 Suppl ISSN: 0160-6689 ISO Abbreviation: J Clin Psychiatry Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-11 Completed Date: 1990-05-11 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 31-41; discussion 42-3 Citation Subset: IM |
Affiliation:
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Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aggression Animals Behavior, Animal / physiology Depressive Disorder / physiopathology* Humans Hydroxyindoleacetic Acid / cerebrospinal fluid* Impulsive Behavior / physiopathology* Models, Biological Research Design Serotonin / metabolism, physiology* Violence* |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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