| CSF serotonin concentrations and cerebral arterial spasm in patients with ruptured intracranial aneurysm. | |
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MedLine Citation:
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PMID: 7064189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 26 patients with recent rupture of an intracranial saccular aneurysm the CSF concentrations of serotonin (5-HT) were measured repeatedly by a radioimmunoassay. The 5-HT level in ventricular CSF collected between the 2nd and 15th day after SAH ranged between less than 2 and 5 nmol/l. These did not differ from the levels found in the ventricular CSF (less than 2-3 nmol/l) and lumbar CSF (less than 2-3 nmol/l) of control patients. 5-HT concentrations did not correlate with the severity of angiographical vasospasm, nor with CSF pressure or clinical grade. In two patients with severe postoperative vasospasm, however, cisternal CSF collected during operation and contaminated by fresh blood showed 5-HT concentrations exceeding 25 nmol/l. Thus, although these results do not support the conception that 5-HT plays a major role in sustaining delayed vasospasm, they suggest that 5-HT liberated from platelets may be operative in the initiation of cerebral arterial spasm. |
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Authors:
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B Voldby; F Engbaek; E M Enevoldsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 13 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1982 Mar-Apr |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 184-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure Female Humans Intracranial Aneurysm / complications* Ischemic Attack, Transient / complications*, radiography Male Middle Aged Rupture, Spontaneous Serotonin / cerebrospinal fluid* Subarachnoid Hemorrhage / complications |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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