Document Detail

CSF production in acute ventriculitis.
MedLine Citation:
PMID:  2647919     Owner:  NLM     Status:  MEDLINE    
Clinically, there appears to be a significant reduction in cerebrospinal fluid (CSF) formation during acute ventriculitis--an observation that has not been well documented by experimental studies. To examine this phenomenon, an inoculum of Escherichia coli was injected into the lateral ventricles of New Zealand White rabbits. Approximately 18 hours later, the survivors (64%) underwent a 3-hour ventriculocisternal perfusion of carbon-14-dextran (MW 7 X 10(4)) as a reference marker for CSF formation. On the average, CSF formation in this experimental group was reduced by one-half to two-thirds of normal, confirming the clinical observation. Histologically, the stroma of the choroid plexus was the site of an extensive inflammatory infiltrate. Meningitis, ependymitis, and focal encephalitis completed the picture. Vasculitis was not present in the choroid plexus. The epithelium of the choroid plexus underwent patchy cellular swelling or frank necrosis and destruction. It is postulated that the changes in the choroid plexus caused by the inflammatory process were responsible for the diminished CSF formation in this acute setting. Reduced choroidal blood flow and/or enterotoxin may play a role in these alterations.
R E Breeze; J G McComb; S Hyman; F H Gilles
Related Documents :
19788029 - Characteristics of cerebrospinal fluid flow in cavalier king charles spaniels analyzed ...
22293429 - Sensitive detection assays for influenza rna do not reveal viremia in us blood donors.
17828699 - Surveillance of occupational blood and body fluid exposures among french healthcare wor...
22895109 - Visualization and analysis of blood flow and oxygen consumption in hepatic microcircula...
18517959 - "bottleneck effect" in two-dimensional microfluidics.
22753729 - Blood vessel normalization in the hamster oral cancer model for experimental cancer the...
22547579 - Infusion of hemolyzed red blood cells within peripheral blood stem cell grafts in patie...
7740499 - Occlusive thrombus formation on indwelling catheters: in vitro investigation and comput...
11237239 - Therapeutic apheresis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  70     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  619-22     Citation Subset:  AIM; IM    
Department of Neurosurgery, University of Southern California School of Medicine, Los Angeles.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Brain / pathology
Cerebral Ventricles*
Cerebrospinal Fluid / physiology*
Encephalitis / etiology,  metabolism*,  pathology
Escherichia coli Infections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C m...
Next Document:  Management of juvenile spinal AVM's by embolization and operative excision. Case report.