Document Detail


CSF production in acute ventriculitis.
MedLine Citation:
PMID:  2647919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinically, there appears to be a significant reduction in cerebrospinal fluid (CSF) formation during acute ventriculitis--an observation that has not been well documented by experimental studies. To examine this phenomenon, an inoculum of Escherichia coli was injected into the lateral ventricles of New Zealand White rabbits. Approximately 18 hours later, the survivors (64%) underwent a 3-hour ventriculocisternal perfusion of carbon-14-dextran (MW 7 X 10(4)) as a reference marker for CSF formation. On the average, CSF formation in this experimental group was reduced by one-half to two-thirds of normal, confirming the clinical observation. Histologically, the stroma of the choroid plexus was the site of an extensive inflammatory infiltrate. Meningitis, ependymitis, and focal encephalitis completed the picture. Vasculitis was not present in the choroid plexus. The epithelium of the choroid plexus underwent patchy cellular swelling or frank necrosis and destruction. It is postulated that the changes in the choroid plexus caused by the inflammatory process were responsible for the diminished CSF formation in this acute setting. Reduced choroidal blood flow and/or enterotoxin may play a role in these alterations.
Authors:
R E Breeze; J G McComb; S Hyman; F H Gilles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  70     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  619-22     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurosurgery, University of Southern California School of Medicine, Los Angeles.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Brain / pathology
Cerebral Ventricles*
Cerebrospinal Fluid / physiology*
Encephalitis / etiology,  metabolism*,  pathology
Escherichia coli Infections
Rabbits

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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