Document Detail


CSF neurotransmitter metabolites in comatose head injury patients during changes in their clinical state.
MedLine Citation:
PMID:  8686526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The main metabolites of noradrenaline, serotonin, and dopamine, methoxyhydroxyphenylglycol (MHPG), 5-hydroxyindole-acetic acid (5HIAA), and homovanillic acid (HVA), respectively, were assessed in CSF samples of patients in coma after severe head injury, the first days after the accident and again after an improvement (13 patients) or deterioration (7 patients) in their clinical state, evaluated by the score on the Glasgow Coma Scale. Improvement was accompanied by significant decreases in HVA and 5HIAA. In the patients who deteriorated, the levels of the three metabolites remained high. The results show that the increased turnover of CNS neurotransmitters in severe head injury normalizes during recovery. The use of noradrenaline, dopamine, and serotonin antagonists in brain injury experimental models may clarify the role of the increased biogenic amine turnover in the processes that lead to recovery. We propose relevant pharmacological intervention influencing neurotransmission in severe head injury.
Authors:
M Markianos; A Seretis; A Kotsou; M Christopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  138     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  1996  
Date Detail:
Created Date:  1996-08-16     Completed Date:  1996-08-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM    
Affiliation:
Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Brain Damage, Chronic / cerebrospinal fluid*,  diagnosis,  rehabilitation
Brain Injuries / cerebrospinal fluid*,  diagnosis,  rehabilitation
Coma / cerebrospinal fluid*,  diagnosis,  rehabilitation
Female
Homovanillic Acid / cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Male
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Middle Aged
Neurologic Examination
Neurotransmitter Agents / cerebrospinal fluid*
Prognosis
Treatment Outcome
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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