Document Detail


CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls.
MedLine Citation:
PMID:  6209989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 114 subjects (41 depressed, 20 schizophrenic, 15 manic, and 38 normal controls) underwent lumbar puncture and their CSF was analyzed for levels of tyrosine, tryptophan, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG), choline, gamma-aminobutyric acid (GABA), and calcium. Results showed that depressed patients, particularly those over 40 years of age, had lower levels of GABA than did controls, and that their level of HVA increased with age, while controls' decreased. Schizophrenic subjects tended to have higher levels of 5-HIAA and manic subjects tended to have higher levels of HVA and MHPG. Age-associated changes were found in HVA, 5-HIAA, MHPG, GABA, and choline concentrations.
Authors:
R H Gerner; L Fairbanks; G M Anderson; J G Young; M Scheinin; M Linnoila; T A Hare; B A Shaywitz; D J Cohen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  141     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1984-12-28     Completed Date:  1984-12-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1533-40     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Bipolar Disorder / cerebrospinal fluid*
Calcium / cerebrospinal fluid
Choline / cerebrospinal fluid
Depressive Disorder / cerebrospinal fluid*
Female
Homovanillic Acid / cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Male
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Middle Aged
Research Design
Schizophrenia / cerebrospinal fluid*
Tryptophan / cerebrospinal fluid
Tyrosine / cerebrospinal fluid
gamma-Aminobutyric Acid / cerebrospinal fluid
Grant Support
ID/Acronym/Agency:
MH-28343/MH/NIMH NIH HHS; RR-05756/RR/NCRR NIH HHS; RR-865/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 56-12-2/gamma-Aminobutyric Acid; 62-49-7/Choline; 73-22-3/Tryptophan; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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