| CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls. | |
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MedLine Citation:
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PMID: 6209989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 114 subjects (41 depressed, 20 schizophrenic, 15 manic, and 38 normal controls) underwent lumbar puncture and their CSF was analyzed for levels of tyrosine, tryptophan, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG), choline, gamma-aminobutyric acid (GABA), and calcium. Results showed that depressed patients, particularly those over 40 years of age, had lower levels of GABA than did controls, and that their level of HVA increased with age, while controls' decreased. Schizophrenic subjects tended to have higher levels of 5-HIAA and manic subjects tended to have higher levels of HVA and MHPG. Age-associated changes were found in HVA, 5-HIAA, MHPG, GABA, and choline concentrations. |
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Authors:
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R H Gerner; L Fairbanks; G M Anderson; J G Young; M Scheinin; M Linnoila; T A Hare; B A Shaywitz; D J Cohen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of psychiatry Volume: 141 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1984-12-28 Completed Date: 1984-12-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1533-40 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Bipolar Disorder / cerebrospinal fluid* Calcium / cerebrospinal fluid Choline / cerebrospinal fluid Depressive Disorder / cerebrospinal fluid* Female Homovanillic Acid / cerebrospinal fluid Humans Hydroxyindoleacetic Acid / cerebrospinal fluid Male Methoxyhydroxyphenylglycol / cerebrospinal fluid Middle Aged Research Design Schizophrenia / cerebrospinal fluid* Tryptophan / cerebrospinal fluid Tyrosine / cerebrospinal fluid gamma-Aminobutyric Acid / cerebrospinal fluid |
| Grant Support | |
ID/Acronym/Agency:
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MH-28343/MH/NIMH NIH HHS; RR-05756/RR/NCRR NIH HHS; RR-865/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 56-12-2/gamma-Aminobutyric Acid; 62-49-7/Choline; 73-22-3/Tryptophan; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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