Document Detail

The CSF levels of total-tau and phosphotau in patients with relapsing-remitting multiple sclerosis.
MedLine Citation:
PMID:  15997419     Owner:  NLM     Status:  MEDLINE    
Total-tau protein is considered the marker of axon damage whereas the abnormally phosphorylated tau forms are mainly associated with Alzheimer's disease. An increase in total-tau levels was observed in neurodegenerative diseases, including multiple sclerosis (MS). In order to find out whether the phosphorylated tau forms occur in MS patients and to evaluate their clinical significance, the levels of total-tau (t-tau) and tau phosphorylated at Thr 181 (p-tau) were determined in 60 MS patients (40 during relapse including 18 with the first relapse and 20 stable) and in 18 age-matched controls. The determinations were conducted in the cerebrospinal fluid (CSF) using the ELISA method. The levels of t-tau and p-tau were higher in MS patients than in controls; however, increased levels were not related to the clinical activity of the disease. In CSF of the patients with the first relapse the level of t-tau was significantly increased whilst the level of p-tau was not elevated.
H Bartosik-Psujek; Z Stelmasiak
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Publication Detail:
Type:  Journal Article     Date:  2005-07-06
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  113     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  IM    
Department of Neurology, Medical University of Lublin, Lublin, Poland.
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MeSH Terms
Biological Markers / analysis,  cerebrospinal fluid
Brain / metabolism*,  pathology,  physiopathology
Cerebrospinal Fluid / metabolism*
Enzyme-Linked Immunosorbent Assay
Microtubules / metabolism,  pathology
Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid*,  diagnosis*,  physiopathology
Predictive Value of Tests
Up-Regulation / physiology
Wallerian Degeneration / cerebrospinal fluid,  diagnosis,  physiopathology
tau Proteins / cerebrospinal fluid*
Reg. No./Substance:
0/Biological Markers; 0/tau Proteins

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