Document Detail

CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias.
MedLine Citation:
PMID:  14739545     Owner:  NLM     Status:  MEDLINE    
The diagnosis of Creutzfeldt-Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD (n = 26) were compared with those in other dementias (n = 28). LDH isoenzymes were determined in a subset (n = 9). Total LDH and isoenzyme LDH-1 were significantly higher, whereas the fractions of LDH-2 and LDH-3 were significantly lower in CJD patients. We conclude that in addition to established CSF parameters, LDH and its isoenzymes might serve as a further help to discriminate between CJD and other dementias.
H Schmidt; M Otto; P Niedmann; L Cepek; A Schröter; H A Kretzschmar; S Poser
Related Documents :
4219095 - Endogenous prostaglandins and the initiation of labor.
18401835 - White adipose tissue production and release of il-6 and tnf-alpha do not parallel circu...
11992875 - Atypical choroidal neovascularization in radiation retinopathy.
22430725 - Body stalk anomaly: adverse maternal outcomes in a series of 21 cases.
8468545 - Spawning in the zebra mussel (dreissena polymorpha): activation by internal or external...
17169515 - Effects of reproductive status and management on cortisol secretion and fertility of oe...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-20
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  17     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-09     Completed Date:  2004-05-03     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  204-6     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Department of Neurology, University of Göttingen, Göttingen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Creutzfeldt-Jakob Syndrome / cerebrospinal fluid*,  enzymology*
Dementia / cerebrospinal fluid*,  enzymology*
Diagnosis, Differential
Isoenzymes / cerebrospinal fluid
L-Lactate Dehydrogenase / cerebrospinal fluid*
Middle Aged
Psychiatric Status Rating Scales
Reg. No./Substance:
0/Isoenzymes; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up st...
Next Document:  Regional cerebral blood flow in Alzheimer's disease: classification and analysis of heterogeneity.