Document Detail


CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies.
MedLine Citation:
PMID:  14504329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.
Authors:
S Nishino; T Kanbayashi; N Fujiki; M Uchino; B Ripley; M Watanabe; G J Lammers; H Ishiguro; S Shoji; Y Nishida; S Overeem; I Toyoshima; Y Yoshida; T Shimizu; S Taheri; E Mignot
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  61     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-23     Completed Date:  2004-04-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  823-5     Citation Subset:  AIM; IM    
Affiliation:
Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA. nishino@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Carrier Proteins / cerebrospinal fluid*
Female
Guillain-Barre Syndrome / cerebrospinal fluid*,  complications
Humans
Intracellular Signaling Peptides and Proteins*
Male
Middle Aged
Miller Fisher Syndrome / cerebrospinal fluid*
Neuropeptides / cerebrospinal fluid*,  deficiency
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / cerebrospinal fluid*
Quadriplegia / cerebrospinal fluid,  etiology
Single-Blind Method
Sleep Disorders / cerebrospinal fluid,  etiology
Grant Support
ID/Acronym/Agency:
MH01600/MH/NIMH NIH HHS; MH40041/MH/NIMH NIH HHS; NS 33797/NS/NINDS NIH HHS; NS23724/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins
Comments/Corrections
Comment In:
Neurology. 2004 Jun 22;62(12):2337; author reply 2337   [PMID:  15210920 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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