Document Detail

CSF flow dynamics in motor neuron disease.
MedLine Citation:
PMID:  22664138     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess cerebrospinal fluid (CSF) flow dynamics involvement in the pathogenesis of amyotrophic lateral sclerosis (ALS), we conducted CSF flow studies on 40 individuals with motor neuron diseases (MNDs) including ALS, and 28 age-matched normal and disease [cervical spondylosis (CS)] controls. METHODS: The CSF pulsatile velocity anterior to the cervical cord at level C5 during one heart beat was determined non-invasively by phase-contrast electrocardiography-triggered magnetic resonance imaging. RESULTS: In MND, caudal CSF velocity peaked at 25% of the cardiac cycle after the R wave (UT(c)/RR), showing an increased delay in comparison to normal controls, while amplitude H(c) was significantly larger than that in CS. DISCUSSION: We conclude that CSF flow dynamics of MND differ from those of controls and may thus facilitate differentiation of MND from CS.
Kota Sato; Nobutoshi Morimoto; Tohru Matsuura; Yasuyuki Ohta; Masatoshi Tsunoda; Yoshio Ikeda; Koji Abe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-30
Journal Detail:
Title:  Neurological research     Volume:  -     ISSN:  1743-1328     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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