Document Detail


CSF cytokine levels in preterm infants may reflect systemic inflammation and are independent of gestation.
MedLine Citation:
PMID:  19019580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Among preterm infants, high concentrations of inflammatory mediators in cerebrospinal fluid (CSF) are associated with poor outcome. Previous studies have not indicated whether CSF concentrations of inflammatory mediators are associated with important confounders such as gestational age. AIMS: To examine associations between CSF concentrations of inflammatory mediators and gestational age, maternal features suggestive of inflammation, characteristics of the CSF sample or the presence of a systemic inflammatory response. STUDY DESIGN AND SUBJECTS: Aliquots of CSF obtained during routine investigation of potential sepsis among infants born before 35 weeks gestation were assayed for 17 mediators of inflammation using a fluorescent multi-bead analyser. Other information was collected from routine clinical records. RESULTS: 39 infants were assessed. CSF levels of mediators of inflammation were not correlated with gestational age. CSF red blood cell counts were correlated with CSF concentrations of IL-6, GM-CSF and IL-17 (each p<0.003). CSF lactate was correlated with CSF concentrations of IL-1beta, IL-6, GM-CSF, G-CSF, IFN-gamma and MIP-1beta. CSF concentrations of IL-1beta, IL-6, G-CSF, TNF-alpha and IFN-gamma were higher in infants with a raised CRP within 24 h of delivery (each p<0.003). CONCLUSIONS: CSF concentrations of inflammatory mediators most probably reflect inflammatory pathologies and are not influenced by gestational age. They may also, however, reflect contamination with blood or systemic inflammation. CSF concentrations of inflammatory mediators may not provide a specific indicator of CNS inflammation.
Authors:
Mark A Turner; Jo A Drury; Andrew Carlin; Susan O'Neill; David Pilling; Nik Barnes; Paul Balmer; Paul Newland; Simon Clark; Christopher M Kissack; Nimish V Subhedar
Publication Detail:
Type:  Journal Article     Date:  2008-11-20
Journal Detail:
Title:  Early human development     Volume:  85     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
Affiliation:
Neonatal Unit, Liverpool Women's Hospital, Crown Street, Liverpool, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Cytokines / cerebrospinal fluid*
Female
Humans
Infant, Newborn
Inflammation / cerebrospinal fluid*
Pregnancy
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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