Document Detail


CSF corticotropin-releasing factor (CRF) in Alzheimer's disease: its relationship to severity of dementia and monoamine metabolites.
MedLine Citation:
PMID:  2477071     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the cerebrospinal fluid (CSF) of 15 probable Alzheimer's disease (AD) patients with mild to moderate dementia and 10 neurologically normal age-matched controls was examined. There were no significant alterations in the mean CSF CRF-LI concentration in AD compared to controls. However, in the AD group, CSF CRF-LI correlated significantly with the global neuropsychological impairment ratings, suggesting that greater cognitive impairment was associated with lower CSF CRF-LI concentrations. There was a significant reduction in the CSF concentration of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the AD patients, and there was a positive correlation between the concentration of CRF-LI and 5-HIAA in CSF. This latter finding suggests that serotoninergic neuronal systems may interact with CRF-containing neurons.
Authors:
N Pomara; R R Singh; D Deptula; P A LeWitt; G Bissette; M Stanley; C B Nemeroff
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  26     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-11-01     Completed Date:  1989-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  500-4     Citation Subset:  IM    
Affiliation:
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / cerebrospinal fluid,  diagnosis*,  psychology
Corticotropin-Releasing Hormone / blood*
Disability Evaluation
Female
Homovanillic Acid / cerebrospinal fluid*
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Male
Middle Aged
Neuropsychological Tests*
Grant Support
ID/Acronym/Agency:
AG-05128/AG/NIA NIH HHS; MH-40524/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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