| CSF cholecystokinin, gamma-aminobutyric acid and neuropeptide Y in pathological gamblers and healthy controls. | |
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MedLine Citation:
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PMID: 17109076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sulphated cholecystokinin (CCK) octapeptide (CCK-8S), the CCK tetrapeptide (CCK-4), neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) were determined in cerebrospinal fluid (CSF) obtained from 11 pathological male gamblers and 11 healthy male controls. Compared with healthy controls, pathological male gamblers displayed higher concentrations of CCK-8S, CCK-4 and GABA (but not NPY). A gradient with decreasing concentrations from the first to the third 6-ml CSF fraction was found for CCK-8S, CCK-4 and NPY, but only in pathological gamblers. Disrupted gradients were found for GABA and for NPY in healthy controls. Given that CCK is a modulator of dopamine in the reward process, the increase in CCK-8S and CCK-4 is not unexpected. The high level of GABA in pathological gamblers is in conformity with a compensatory inhibitory action on noradrenergic neurons. The CSF gradient of CCK-8S and CCK-4 in pathological male gamblers (but not healthy controls) might indicate a difference in diurnal variation. The results obtained are in line with an altered CCK and GABA function in pathological gambling. |
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Authors:
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C Nordin; I Sjödin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-17 |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 114 ISSN: 0300-9564 ISO Abbreviation: J Neural Transm Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-23 Completed Date: 2007-10-04 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: Austria |
Other Details:
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Languages: eng Pagination: 499-503 Citation Subset: IM |
Affiliation:
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Department of Neuroscience and Locomotion, Psychiatry Section, Faculty of Health Sciences, Linköping University, Linköping, Sweden. conny.nordin@inr.liu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholecystokinin / cerebrospinal fluid* Female Gambling* Humans Impulse Control Disorders / cerebrospinal fluid* Male Neuropeptide Y / cerebrospinal fluid* gamma-Aminobutyric Acid / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 56-12-2/gamma-Aminobutyric Acid; 9011-97-6/Cholecystokinin |
| Comments/Corrections | |
Erratum In:
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J Neural Transm. 2007;114(5):687 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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