| CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. | |
| | |
MedLine Citation:
|
PMID: 20381883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS. |
| | |
Authors:
|
Takahisa Tateishi; Ryo Yamasaki; Masahito Tanaka; Takuya Matsushita; Hitoshi Kikuchi; Noriko Isobe; Yasumasa Ohyagi; Jun-ichi Kira |
Related Documents
:
|
11526983 - Intrathecal levels of complement-derived soluble membrane attack complex (sc5b-9) corre... 9382473 - Prospective study of neurological responses to treatment with macrophage-targeted gluco... 6623013 - Ankylosing spondylitis of juvenile onset: comparison with adult onset disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-09 |
Journal Detail:
|
Title: Journal of neuroimmunology Volume: 222 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-27 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 76-81 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Amyotrophic Lateral Sclerosis / cerebrospinal fluid*, immunology* Biological Markers / analysis, cerebrospinal fluid Cerebrospinal Fluid Proteins / analysis, metabolism* Chemokine CCL2 / analysis, cerebrospinal fluid Chemokine CCL4 / analysis, cerebrospinal fluid Chemokine CXCL10 / analysis, cerebrospinal fluid Chemokines / analysis, cerebrospinal fluid* Down-Regulation / immunology Female Fluorescence Polarization Immunoassay Humans Interleukin-8 / analysis, cerebrospinal fluid Male Middle Aged Predictive Value of Tests Sensitivity and Specificity Up-Regulation / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/CCL2 protein, human; 0/Cerebrospinal Fluid Proteins; 0/Chemokine CCL2; 0/Chemokine CCL4; 0/Chemokine CXCL10; 0/Chemokines; 0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of P3 amplitude to treatment completion in substance dependent individuals.
Next Document: A 13-year experience and predictors for success in transnasal endoscopic repair of congenital choana...