Document Detail

CSF beta-endorphin, HVA and 5-HIAA of dementia of the Alzheimer type and Binswanger's disease in the elderly.
MedLine Citation:
PMID:  1697333     Owner:  NLM     Status:  MEDLINE    
Cerebrospinal fluid (CSF) concentration of beta-endorphin (beta-Ep), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) was measured in 15 patients with dementia of the Alzheimer type (DAT) and in 16 patients suspected of having Binswanger's disease (BD) by MRI, which sometimes resembles DAT clinically. These were classified into three stages according to severity of dementia, Stage 1 (mild dementia)-Stage 3 (severe dementia). CSF levels of HVA decreased significantly in severe dementia, but the level of 5-HIAA did not correlate with dementia severity in both dementia groups. beta-Ep levels did not differ significantly between any stages of DAT, and among controls. beta-Ep levels, however, in BD Stage 1 (27.5 +/- 5.9 pg/ml) were significantly higher (p less than 0.05), but level in Stage 3 (6.7 +/- 2.0) was significantly lower (p less than 0.001) than in the controls (19.2 +/- 4.5). These results suggest that CSF beta-Ep may depend on the cause of dementia rather than severity of dementia, and could possibly distinguish the closely resembling BD from true DAT.
S Lee; T Chiba; T Kitahama; R Kaieda; M Hagiwara; A Nagazumi; A Terashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neural transmission. Supplementum     Volume:  30     ISSN:  0303-6995     ISO Abbreviation:  J. Neural Transm. Suppl.     Publication Date:  1990  
Date Detail:
Created Date:  1990-10-04     Completed Date:  1990-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425126     Medline TA:  J Neural Transm Suppl     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  45-55     Citation Subset:  IM    
Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Alzheimer Disease / cerebrospinal fluid*,  diagnosis
Dementia / cerebrospinal fluid*,  diagnosis
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Magnetic Resonance Imaging
Mental Status Schedule
beta-Endorphin / cerebrospinal fluid*
Reg. No./Substance:
306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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