Document Detail

CSF acid-base regulation and ventilation during acute hypercapnia in the newborn dog.
MedLine Citation:
PMID:  6788736     Owner:  NLM     Status:  MEDLINE    
We studied the response of blood, cerebrospinal fluid (CSF), and brain ionic composition and acid-base status as well as ventilation to acute respiratory acidosis (FICO2 0.08) in lightly anesthetized newborn puppies. Control puppy plasma ions and CSF-plasma ionic distribution ratios were essentially adultlike while in blood a mild, compensated respiratory acidosis was present, and in CSF, PCO2 and [HCO3-] were slightly higher than in adults. Brain tissue water content was higher in puppy vs. adult; the Cl- space was greater; the content of [Na+], [Cl-], and [HCO3-] were higher and [K+] lower. During respiratory acidosis, CSF [HCO3-] increased 2.0 mmol/l by 15 min and 6.2 mmol/l by 3 h, a response quantitatively like that observed in the adult. The quantity, CSF [Na+] -- [Cl-], increased stoichiometrically with CSF [HCO3-], indicating the mechanistic involvement of these ions in the CSF [HCO3-] response. In brain tissue, water content, [Cl-], and the [Cl-] space were unchanged, but by 3 h [Na+] and [HCO3-] were increased. Ventilation was stimulated but the response expressed as ml.min-1.Torr-1.body wt-1 was less in puppy than in adult.
E E Nattie; W H Edwards
Related Documents :
16643646 - The prolongation of somatic support in a pregnant woman with brain-death: a case report.
11651986 - Brain death and brain life: rethinking the connection.
20004536 - Reduced cerebellar diameter in very preterm infants with abnormal general movements.
626076 - Brain-typical creatinekinase in the serum of newborn infants with perinatal brain damage.
23739256 - Three-dimensional comparison in palatal forms between modified presurgical nasoalveolar...
1842536 - Bad outcomes in black babies: race or racism?
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  50     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  566-74     Citation Subset:  IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acid-Base Equilibrium*
Animals, Newborn / physiology*
Bicarbonates / metabolism
Biological Transport
Brain / metabolism
Carbon Dioxide / metabolism
Cerebrospinal Fluid / metabolism,  physiology*
Chlorides / metabolism
Hypercapnia / physiopathology*
Oxygen Consumption
Potassium / metabolism
Sodium / metabolism
Grant Support
00364//PHS HHS; 18351//PHS HHS
Reg. No./Substance:
0/Bicarbonates; 0/Chlorides; 124-38-9/Carbon Dioxide; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Volume, flow, and timing of each breath during negative airway pressure in humans.
Next Document:  Association of 6-oxo-piperidine-2-carboxylic acid with penicillin V. Production on Penicillium chrys...