| CSF neutrophils are implicated in the development of vasospasm in subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 19967568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cerebral vasospasm is a significant cause of morbidity in patients after aneurysmal subarachnoid hemorrhage (aSAH). There are few effective treatments. The search for new treatments has focused predominantly on dilating cerebral blood vessels. Growing evidence supports a role for inflammation in its pathogenesis but no potential target for intervention has emerged. METHODS: CSF and clinical information from patients with aSAH were collected. Additionally, tyrosine modifications by stable isotope dilution HPLC with online tandem mass spectrometry were quantified in CSF samples. RESULTS: We report an association between neutrophil accumulation in the cerebrospinal fluid of patients with aSAH and the development of vasospasm. In particular, CSF neutrophil content of >62% on the third day after aSAH is an independent predictor of the later development of vasospasm (OR 6.8, 95% CI 2.0-23.3, P = 0.002). Further, activity of myeloperoxidase and NADPH oxidase is elevated in aSAH suggesting a role for modification of CSF proteins by reactive oxidant species. CONCLUSIONS: Neutrophil percentage is an independent predictor of vasospasm in aSAH patients, days prior to its onset suggesting a role of neutrophils in vasospasm. The activity of neutrophil enzymes is also increased suggesting a mechanism for blood vessel damage. Inflammation mediated by neutrophils is a potential target for therapies in vasospasm. More study is necessary to determine the mechanism by which neutrophils damage cerebral blood vessels. |
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Authors:
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J J Provencio; X Fu; A Siu; P A Rasmussen; S L Hazen; R M Ransohoff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neurocritical care Volume: 12 ISSN: 1556-0961 ISO Abbreviation: Neurocrit Care Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-06-23 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 101156086 Medline TA: Neurocrit Care Country: United States |
Other Details:
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Languages: eng Pagination: 244-51 Citation Subset: IM |
Affiliation:
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NB3, Neuroinflammation Research Center, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA. provenj@ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Humans Male Middle Aged Neutrophils / metabolism* Reactive Oxygen Species / cerebrospinal fluid Subarachnoid Hemorrhage / cerebrospinal fluid*, complications, physiopathology* Tandem Mass Spectrometry Tyrosine / analogs & derivatives, cerebrospinal fluid Vasospasm, Intracranial / cerebrospinal fluid*, complications |
| Grant Support | |
ID/Acronym/Agency:
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K08 NS051350/NS/NINDS NIH HHS; K08 NS051350-03/NS/NINDS NIH HHS; K24 NS51400/NS/NINDS NIH HHS; P01HL076491/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 0/bromotyrosine; 55520-40-6/Tyrosine; 7298-90-0/3-chlorotyrosine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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