Document Detail

CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans.
MedLine Citation:
PMID:  22294808     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: Hypocretin (orexin) is a unique neuropeptide involved in the consolidation of wakefulness and sleep. Although hypocretin-1 levels in the cerebrospinal fluid (CSF) are stable after infancy, how levels change in preterm and term human infants is unknown.
DESIGN, PATIENTS, AND SETTING: Hypocretin-1 levels were measured in CSF samples, obtained from 284 preterm (25-37 gestational weeks) and full-term infants in the first 4 months of life and 35 older children (ages 0.5-13 years), in a tertiary hospital.
MEASUREMENTS AND RESULTS: Detailed clinical and laboratory data were collected for each of the 319 participants. Based on that data, 108 neurologically intact children were selected (95 infants [43 preterm and 52 term] and 13 older children). CSF hypocretin-1 was measured by direct radioimmunoassay. Hypocretin-1 levels at the first weeks of the 3rd embryonic trimester (gestational age [GA] 28-34 weeks) were 314 ± 65 pg/mL (n = 17). The levels linearly increased during the third trimester and early infancy (r = 0.6), peaking in infants of 2-4 months ages (476 ± 72 pg/mL; n = 16) and decreasing thereafter; hypocretin levels in 2- to 4-month-old infants were significantly higher than those in children 0.5-13 years old (353 ± 78 pg/mL, n = 13; P = 0.0001).
CONCLUSIONS: The present findings indicate that in human infants, CSF hypocretin-1 increases during the third embryonic trimester and is highest at 4 months of life. Thereafter, and consistent with previously published results, hypocretin levels are lower and stable until the geriatric age. This pattern may reflect the role of hypocretin in the dramatic process of sleep and wakefulness consolidation that occurs during early infancy.
Adi Aran; Irina Shors; Ling Lin; Emmanuel Mignot; Michael S Schimmel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-01
Journal Detail:
Title:  Sleep     Volume:  35     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-01     Completed Date:  2012-06-19     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-91     Citation Subset:  IM    
Neuropediatric Unit, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.
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MeSH Terms
Age Factors
Child, Preschool
Infant, Newborn / cerebrospinal fluid*
Infant, Premature / cerebrospinal fluid*
Intracellular Signaling Peptides and Proteins / cerebrospinal fluid*
Neuropeptides / cerebrospinal fluid*
Radioimmunoassay / methods
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins
Comment In:
Sleep. 2012 Feb;35(2):171-2   [PMID:  22294804 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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