Document Detail


The CSF Concentration of ADMA, but not of ET-1, is Correlated with the Occurrence and Severity of Cerebral Vasospasm after Subarachnoid Hemorrhage.
MedLine Citation:
PMID:  22796469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Under physiological conditions, vasoconstrictors and vasodilators are counterbalanced. After aneurysmal subarachnoid hemorrhage (SAH) disturbance of this equilibrium may evoke delayed cerebral vasospasm (CVS) leading to delayed cerebral ischemia (DCI). Most studies examined either the vasoconstrictor endothelin-1 (ET-1) or the vasodilative pathway of nitric oxide (NO) and did not include investigations regarding the relationship between vasospasm and ischemia. Asymmetric dimethyl-L-arginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), decreases the concentration of NO. Studies have correlated increasing concentrations of ADMA with the course and degree of CVS after SAH. We sought to determine, if ADMA and endothelin-1 (ET-1) are associated with CVS and/or DCI after SAH. MATERIALS AND METHODS: CSF concentrations of ADMA and ET-1 were retrospectively determined in 30 patients after SAH and in controls. CVS was detected clinically and by arteriogaphy. DCI was monitored by follow-up CT scans. RESULTS: 17 patients developed arteriographic CVS and 4 patients developed DCI. ADMA but not ET-1 concentrations were correlated with occurrence and degree of CVS. However, ET-1 concentrations were correlated with WFNS grade on admission. Neither ADMA nor ET-1 correlated with DCI in this cohort. CONCLUSION: ET-1 concentrations seem to be associated with the impact of the SAH bleed. ADMA may be directly involved in the development and resolution of CVS after SAH via inhibition of NOS disturbing the balance of vasodilative and -constrictive components.
Authors:
Carla S Jung; Bettina Lange; Michael Zimmermann; Volker Seifert
Related Documents :
11466019 - A prospective comparison between two seizure classifications.
19942389 - Nationwide survey (incidence, clinical course, prognosis) of rasmussen's encephalitis.
18468459 - Does the seizure frequency increase in ramadan?
11605699 - Seizures in patients with multiple sclerosis seen at mayo clinic, rochester, minn, 1990...
10190379 - Neuroglycopenic and other symptoms in patients with insulinomas.
12609269 - Clinical presentations of naturally occurring canine seizures: similarities to human se...
8185519 - Ocular manifestations of leprosy in a noninstitutionalized community in the united states.
24622939 - Clinical analysis of brain trauma-associated siadh.
1192079 - Incidence of metal sensitivity in patients with total joint replacements.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Neuroscience letters     Volume:  -     ISSN:  1872-7972     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Neurosurgery, Johann-Wolfgang Goethe University, Frankfurt and; Department of Neurosurgery, Ruprecht-Karls University, Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model.
Next Document:  5'-Aza-dC sensitizes paraquat toxic effects on PC12 cell.