| CSF Aβ1-42 Levels and Glucose Metabolism in Alzheimer's Disease> | |
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MedLine Citation:
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PMID: 21897007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Glucose dysmetabolism has been consistently associated with an increased risk of cognitive disorders, and brain insulin resistance could play a role in Alzheimer's disease (AD) pathogenesis. Recent evidence suggests that cerebrospinal fluid (CSF) biomarkers may reflect the brain pathology in AD. We have investigated the relationship between CSF concentrations of amyloid-β peptide 1-42 (Aβ1-42), total tau, and phosphorylated tau (ptau-181) and plasma and CSF glucose levels in a cohort of 94 newly diagnosed non-diabetics AD patients. We report that CSF Aβ1-42 level was inversely associated with CSF to plasma glucose ratio (Spearman's coefficient = -0.27, p = 0.008). This relationship remained after adjustment for age, gender, body mass index, hypertension, and MMSE score (β [SE] of linear regression = -0.93 [0.37], p = 0.01). In stratified analysis, this relationship was observed only in patients who did not carry the apolipoprotein E4 allele. No significant relationship was found between glucose levels and total tau or phosphorylated tau 181. These results support the idea that a link between glucose dysmetabolism and the amyloid pathway may exist in the pathogenesis of AD. |
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Authors:
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Julien Dumurgier; Claire Paquet; Katell Peoc'h; Pauline Lapalus; François Mouton-Liger; Sarah Benisty; Stéphanie Chasseigneaux; Hughes Chabriat; Jacques Hugon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: - ISSN: 1875-8908 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre Mémoire de Ressources et de Recherche (CMRR) Paris Nord Ile-de-France, Lariboisière - Fernand Widal Hospital, APHP, University Paris 7-Denis Diderot, Paris, France INSERM Neuroepidemiology, Hôpital la Salpêtrière, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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