Document Detail


CRTAM: A molecule involved in epithelial cell adhesion.
MedLine Citation:
PMID:  20556794     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Class I-restricted T cell associated molecule (CRTAM) is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin-like proteins. Here we demonstrate for the first time, that CRTAM is expressed in epithelial cells along the lateral membrane and is important for early cell-cell contacts and cell-substrate interactions. CRTAM is sensitive to intermediate filament disruption and treatment of monolayers with soluble CRTAM enhances cell-cell dissociation and lowers transepithelial electrical resistance. Incubation of newly plated cells with anti-CRTAM antibody decreases the formation of cell aggregates and promotes cell detachment. Co-cultures of epithelial cells and fibroblasts that lack CRTAM expression and in vitro binding assays, demonstrate the participation of CRTAM in homotypic and heterotypic trans-interactions. Hence we conclude that CRTAM is a molecule involved in epithelial cell adhesion.
Authors:
Erika Garay; Genaro Patiño-López; Socorro Islas; Lourdes Alarcón; Elsy Canche-Pool; Ricardo Valle-Rios; Oscar Medina-Contreras; Giovana Granados; Bibiana Chávez-Munguía; Eusebio Juaristi; Vianney Ortiz-Navarrete; Lorenza González-Mariscal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  111     ISSN:  1097-4644     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-22     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Affiliation:
Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies Cinvestav, Mexico City, Mexico.
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