| CRT improves the exercise capacity and functional reserve of the failing heart through enhancing the cardiac flow- and pressure-generating capacity. | |
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MedLine Citation:
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PMID: 16377239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: While information on how cardiac resynchronisation therapy (CRT) affects cardiac performance at rest is readily available, the mechanisms whereby CRT alters cardiac function during maximal exercise are unclear. AIMS: We examined the medium-term effects of CRT on cardiac and physical functional reserve of patients with severe heart failure (CHF) and prolonged QRS duration. METHODS: Seventeen consecutive patients with severe CHF (NYHA III-IV) and widened QRS underwent maximal cardiopulmonary exercise testing with non-invasive central haemodynamic measurements before and 6-8 weeks after CRT pacemaker implantation. RESULTS: After CRT there were significant increases in exercise cardiac output by 19.3% (P=0.0048) from 9.5+/-3.4 l min(-1), peak mean arterial blood pressure by 14.1% (P=0.0001) from 91.3+/-13.6 mm Hg, and peak cardiac power output by 37.2% (P=0.0008) from 1.92+/-0.74 W. There were no significant changes in these variables at rest. Exercise duration (+42.3%, P=0.0002), NYHA functional class (P=0.0001) and SF-36 symptom score (P=0.0006) were also significantly improved. Powerful surrogate indicators of prognosis were also significantly improved with CRT: peak O(2) consumption (+20.9%, P=0.0007), VE/VCO(2) slope (-20.0%, P=0.005) and circulatory power (+42.0%, P=0.0012). CONCLUSION: In this cohort of patients, post-implant CRT significantly improved the flow-, pressure- and power-generating capacity of the failing hearts. This may be causally related to the improvements observed in exercise capacity, functional class and symptom scores. |
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Authors:
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D Schlosshan; D Barker; C Pepper; G Williams; C Morley; L-B Tan |
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Publication Detail:
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Type: Journal Article Date: 2005-12-27 |
Journal Detail:
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Title: European journal of heart failure Volume: 8 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-18 Completed Date: 2006-12-12 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 515-21 Citation Subset: IM |
Affiliation:
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Molecular Cardiovascular Medicine, University of Leeds, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Output Cardiac Pacing, Artificial* Exercise Test Exercise Tolerance* Female Follow-Up Studies Health Status Indicators Heart Failure / physiopathology*, therapy* Heart Rate Humans Male Middle Aged Oxygen Consumption Pacemaker, Artificial Prospective Studies Quality of Life Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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