| CRP measurement: does the assay matter in hemodialysis patients? | |
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MedLine Citation:
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PMID: 19049707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The serum level of C-reactive protein, an acute-phase marker of systemic inflammation, has been shown to predict cardiovascular events in the general population and cardiovascular and total mortality in hemodialysis patients. High-sensitivity CRP assays (hs-CRP) have been used in numerous studies. We hypothesized that the level of CRP as measured by the conventional assay (c-CRP) would predict mortality in hemodialysis patients with an accuracy similar to that of high-sensitivity assays. METHODS: In April 2001 CRP serum level was measured with both a conventional and a high-sensitivity assay in 102 prevalent hemodialysis patients. Mortality was prospectively monitored over 6 years. RESULTS: 49 patients (48%) died during follow-up. With both assays, almost 2/3 of patients had high CRP levels (> 1 mg/dl). Survival at 6 years was significantly lower in patients with high CRP levels, no matter which assay was used (31.5% for patients with high hs-CRP and 27.3% for patients with high c-CRP vs 48.4% for patients with low hs-CRP and 47.1% for patients with low c-CRP). Cardiovascular mortality was also higher in patients with high CRP levels, whatever the type of assay (conventional or high sensitivity) used. The correlation between the two tests was excellent. CONCLUSION: CRP level, measured by a conventional inexpensive assay, is predictive of mortality in hemodialysis patients. |
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Authors:
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N Kanaan; E Goffin; D Maisin; J Struyven; M Jadoul |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 70 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-03 Completed Date: 2009-03-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 503-7 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. nada.Kanaan@uclouvain.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Belgium / epidemiology Biological Markers / blood C-Reactive Protein / metabolism* Cardiovascular Diseases / blood*, epidemiology, etiology Female Follow-Up Studies Humans Incidence Kidney Failure, Chronic / blood*, complications, therapy Male Middle Aged Nephelometry and Turbidimetry Prognosis Prospective Studies Renal Dialysis* Risk Factors Survival Rate / trends Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9007-41-4/C-Reactive Protein |
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