Document Detail

CRP measurement: does the assay matter in hemodialysis patients?
MedLine Citation:
PMID:  19049707     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The serum level of C-reactive protein, an acute-phase marker of systemic inflammation, has been shown to predict cardiovascular events in the general population and cardiovascular and total mortality in hemodialysis patients. High-sensitivity CRP assays (hs-CRP) have been used in numerous studies. We hypothesized that the level of CRP as measured by the conventional assay (c-CRP) would predict mortality in hemodialysis patients with an accuracy similar to that of high-sensitivity assays. METHODS: In April 2001 CRP serum level was measured with both a conventional and a high-sensitivity assay in 102 prevalent hemodialysis patients. Mortality was prospectively monitored over 6 years. RESULTS: 49 patients (48%) died during follow-up. With both assays, almost 2/3 of patients had high CRP levels (> 1 mg/dl). Survival at 6 years was significantly lower in patients with high CRP levels, no matter which assay was used (31.5% for patients with high hs-CRP and 27.3% for patients with high c-CRP vs 48.4% for patients with low hs-CRP and 47.1% for patients with low c-CRP). Cardiovascular mortality was also higher in patients with high CRP levels, whatever the type of assay (conventional or high sensitivity) used. The correlation between the two tests was excellent. CONCLUSION: CRP level, measured by a conventional inexpensive assay, is predictive of mortality in hemodialysis patients.
N Kanaan; E Goffin; D Maisin; J Struyven; M Jadoul
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  70     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  IM    
Department of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
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MeSH Terms
Aged, 80 and over
Belgium / epidemiology
Biological Markers / blood
C-Reactive Protein / metabolism*
Cardiovascular Diseases / blood*,  epidemiology,  etiology
Follow-Up Studies
Kidney Failure, Chronic / blood*,  complications,  therapy
Middle Aged
Nephelometry and Turbidimetry
Prospective Studies
Renal Dialysis*
Risk Factors
Survival Rate / trends
Time Factors
Young Adult
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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