Document Detail


CRH test after pituitary microsurgery suggests tertiary adrenocortical insufficiency in successful operated patients with Cushing's disease.
MedLine Citation:
PMID:  2832294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study 30 patients with ACTH-dependent Cushing's disease underwent CRH-stimulation test before, 7-10 days and 3-6 months later after transphenoidal selective microadenomectomy. In 22 of 30 patients clinical and endocrinological remission (2 mg dexamethasone suppression test below 2 micrograms/dl cortisol) occurred. Fourteen of the 22 patients in remission showed a statistically significant increase of ACTH after CRH, 1 week after the operation. This CRH-induced ACTH increase in the early post-operative period gives indirect evidence for endogenous CRH deficiency and suggests tertiary adrenocortical insufficiency in successfully operated patients.
Authors:
U Schrell; R Fahlbusch; M Buchfelder; S Riedl; G K Stalla; O A Müller
Related Documents :
10914434 - Accelerated growth and improved nutritional status after recombinant human growth hormo...
16645014 - Transsphenoidal pituitary surgery via the endoscopic technique: results in 35 consecuti...
9974084 - Strength and its relationship to changes in fat-free mass, total body potassium, total ...
11504104 - Adrenocorticotropic hormone-producing pituitary tumors: 12- to 22-year follow-up after ...
8362944 - Intraamniotic 15(s)-15-methyl prostaglandin f2 alpha and termination of middle and late...
8976244 - A randomized study to compare biodegradable self-reinforced polyglycolic acid spiral st...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research. Supplement series     Volume:  16     ISSN:  0170-5903     ISO Abbreviation:  Horm. Metab. Res. Suppl.     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-10     Completed Date:  1988-05-10     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  0330417     Medline TA:  Horm Metab Res Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  64-5     Citation Subset:  IM    
Affiliation:
Neurochirurgische Klinik, University of Erlangen-Nürberg, West Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenoma / complications,  surgery*
Adrenal Cortex / physiopathology
Adrenal Insufficiency / etiology*,  physiopathology
Adrenocorticotropic Hormone / secretion*
Corticotropin-Releasing Hormone / diagnostic use*
Cushing Syndrome / etiology*,  physiopathology,  surgery
Humans
Microsurgery
Pituitary Neoplasms / complications,  surgery*
Chemical
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The use of CRF-41 in the differential diagnosis of Cushing's syndrome and obesity.
Next Document:  Bilateral and simultaneous sinus petrosus inferior catheterization in patients with Cushing's syndro...