| CRH test after pituitary microsurgery suggests tertiary adrenocortical insufficiency in successful operated patients with Cushing's disease. | |
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MedLine Citation:
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PMID: 2832294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study 30 patients with ACTH-dependent Cushing's disease underwent CRH-stimulation test before, 7-10 days and 3-6 months later after transphenoidal selective microadenomectomy. In 22 of 30 patients clinical and endocrinological remission (2 mg dexamethasone suppression test below 2 micrograms/dl cortisol) occurred. Fourteen of the 22 patients in remission showed a statistically significant increase of ACTH after CRH, 1 week after the operation. This CRH-induced ACTH increase in the early post-operative period gives indirect evidence for endogenous CRH deficiency and suggests tertiary adrenocortical insufficiency in successfully operated patients. |
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Authors:
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U Schrell; R Fahlbusch; M Buchfelder; S Riedl; G K Stalla; O A Müller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone and metabolic research. Supplement series Volume: 16 ISSN: 0170-5903 ISO Abbreviation: Horm. Metab. Res. Suppl. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-05-10 Completed Date: 1988-05-10 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 0330417 Medline TA: Horm Metab Res Suppl Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 64-5 Citation Subset: IM |
Affiliation:
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Neurochirurgische Klinik, University of Erlangen-Nürberg, West Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications,
surgery* Adrenal Cortex / physiopathology Adrenal Insufficiency / etiology*, physiopathology Adrenocorticotropic Hormone / secretion* Corticotropin-Releasing Hormone / diagnostic use* Cushing Syndrome / etiology*, physiopathology, surgery Humans Microsurgery Pituitary Neoplasms / complications, surgery* |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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