Document Detail

CRH test after pituitary microsurgery suggests tertiary adrenocortical insufficiency in successful operated patients with Cushing's disease.
MedLine Citation:
PMID:  2832294     Owner:  NLM     Status:  MEDLINE    
In this study 30 patients with ACTH-dependent Cushing's disease underwent CRH-stimulation test before, 7-10 days and 3-6 months later after transphenoidal selective microadenomectomy. In 22 of 30 patients clinical and endocrinological remission (2 mg dexamethasone suppression test below 2 micrograms/dl cortisol) occurred. Fourteen of the 22 patients in remission showed a statistically significant increase of ACTH after CRH, 1 week after the operation. This CRH-induced ACTH increase in the early post-operative period gives indirect evidence for endogenous CRH deficiency and suggests tertiary adrenocortical insufficiency in successfully operated patients.
U Schrell; R Fahlbusch; M Buchfelder; S Riedl; G K Stalla; O A Müller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research. Supplement series     Volume:  16     ISSN:  0170-5903     ISO Abbreviation:  Horm. Metab. Res. Suppl.     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-10     Completed Date:  1988-05-10     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  0330417     Medline TA:  Horm Metab Res Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  64-5     Citation Subset:  IM    
Neurochirurgische Klinik, University of Erlangen-Nürberg, West Germany.
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MeSH Terms
Adenoma / complications,  surgery*
Adrenal Cortex / physiopathology
Adrenal Insufficiency / etiology*,  physiopathology
Adrenocorticotropic Hormone / secretion*
Corticotropin-Releasing Hormone / diagnostic use*
Cushing Syndrome / etiology*,  physiopathology,  surgery
Pituitary Neoplasms / complications,  surgery*
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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