| CRH-stimulated cortisol release and food intake in healthy, non-obese adults. | |
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MedLine Citation:
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PMID: 19828258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is considerable anecdotal and some scientific evidence that stress triggers eating behavior, but underlying physiological mechanisms remain uncertain. The hypothalamic-pituitary-adrenal (HPA) axis is a key mediator of physiological stress responses and may play a role in the link between stress and food intake. Cortisol responses to laboratory stressors predict consumption but it is unclear whether such responses mark a vulnerability to stress-related eating or whether cortisol directly stimulates eating in humans. METHODS: We infused healthy adults with corticotropin-releasing hormone (CRH) at a dose that is subjectively undetectable but elicits a robust endogenous cortisol response, and measured subsequent intake of snack foods, allowing analysis of HPA reactivity effects on food intake without the complex psychological effects of a stress paradigm. RESULTS: CRH elevated cortisol levels relative to placebo but did not impact subjective anxious distress. Subjects ate more following CRH than following placebo and peak cortisol response to CRH was strongly related to both caloric intake and total consumption. CONCLUSIONS: These data show that HPA axis reactivity to pharmacological stimulation predicts subsequent food intake and suggest that cortisol itself may directly stimulate food consumption in humans. Understanding the physiological mechanisms that underlie stress-related eating may prove useful in efforts to attack the public health crises created by obesity. |
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Authors:
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Sophie A George; Samir Khan; Hedieh Briggs; James L Abelson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-13 |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 35 ISSN: 1873-3360 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-06-17 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 607-12 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Psychiatry, University of Michigan, Trauma, Stress and Anxiety Research Group, 4250 Plymouth Rd (Box 5765), Ann Arbor, MI 48109-2700, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anxiety / blood, metabolism Corticotropin-Releasing Hormone / administration & dosage, pharmacology* Double-Blind Method Eating / drug effects*, physiology Feeding Behavior / drug effects, psychology Female Health* Humans Hydrocortisone / blood, metabolism* Hypothalamo-Hypophyseal System / drug effects, metabolism Ideal Body Weight / physiology Male Obesity / metabolism Pituitary-Adrenal System / drug effects, metabolism Placebos Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000042-475670/RR/NCRR NIH HHS; R01 MH052724-09/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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