Document Detail


CRH-stimulated cortisol release and food intake in healthy, non-obese adults.
MedLine Citation:
PMID:  19828258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is considerable anecdotal and some scientific evidence that stress triggers eating behavior, but underlying physiological mechanisms remain uncertain. The hypothalamic-pituitary-adrenal (HPA) axis is a key mediator of physiological stress responses and may play a role in the link between stress and food intake. Cortisol responses to laboratory stressors predict consumption but it is unclear whether such responses mark a vulnerability to stress-related eating or whether cortisol directly stimulates eating in humans.
METHODS: We infused healthy adults with corticotropin-releasing hormone (CRH) at a dose that is subjectively undetectable but elicits a robust endogenous cortisol response, and measured subsequent intake of snack foods, allowing analysis of HPA reactivity effects on food intake without the complex psychological effects of a stress paradigm.
RESULTS: CRH elevated cortisol levels relative to placebo but did not impact subjective anxious distress. Subjects ate more following CRH than following placebo and peak cortisol response to CRH was strongly related to both caloric intake and total consumption.
CONCLUSIONS: These data show that HPA axis reactivity to pharmacological stimulation predicts subsequent food intake and suggest that cortisol itself may directly stimulate food consumption in humans. Understanding the physiological mechanisms that underlie stress-related eating may prove useful in efforts to attack the public health crises created by obesity.
Authors:
Sophie A George; Samir Khan; Hedieh Briggs; James L Abelson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-13
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  35     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-06-17     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anxiety / blood,  metabolism
Corticotropin-Releasing Hormone / administration & dosage,  pharmacology*
Double-Blind Method
Eating / drug effects*,  physiology
Feeding Behavior / drug effects,  psychology
Female
Health*
Humans
Hydrocortisone / blood,  metabolism*
Hypothalamo-Hypophyseal System / drug effects,  metabolism
Ideal Body Weight / physiology
Male
Obesity / metabolism
Pituitary-Adrenal System / drug effects,  metabolism
Placebos
Young Adult
Grant Support
ID/Acronym/Agency:
M01 RR000042/RR/NCRR NIH HHS; M01 RR000042-475670/RR/NCRR NIH HHS; R01 MH052724/MH/NIMH NIH HHS; R01 MH052724-09/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Placebos; 9015-71-8/Corticotropin-Releasing Hormone; WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

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