| CRF1 receptor antagonist CP-154,526 reduces cardiovascular responses during acute psychological stress in rabbits. | |
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MedLine Citation:
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PMID: 15261120 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effect of CP-154,526 on cardiovascular changes elicited in conscious rabbits by stressful stimuli (loud sound, cage move, pinprick, formaldehyde vapour and air-jet stress). CP-154,526 substantially reduced pressor and heart rate responses to these stimuli (both vagally and sympathetically mediated), and reduced QT shortening during air-jet stress. Blocking of central CRF1 receptors attenuates cardiovascular responses to environmental stimuli, presumably by affecting brain centres that control cardiovascular functions. |
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Authors:
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E Nalivaiko; W W Blessing |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 1017 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-20 Completed Date: 2004-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 234-7 Citation Subset: IM |
Affiliation:
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Department of Physiology, Centre for Neuroscience, Flinders University, Australia. eugene.nalivaiko@flinders.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Animals Blood Pressure / drug effects* Electroencephalography / methods Heart Rate / drug effects* Propranolol / pharmacology Pyrimidines / pharmacology* Pyrroles / pharmacology* Rabbits Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*, physiology Stress, Psychological / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/CP 154526; 0/Pyrimidines; 0/Pyrroles; 0/Receptors, Corticotropin-Releasing Hormone; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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