Document Detail

CRF1 receptor antagonist CP-154,526 reduces cardiovascular responses during acute psychological stress in rabbits.
MedLine Citation:
PMID:  15261120     Owner:  NLM     Status:  MEDLINE    
We examined the effect of CP-154,526 on cardiovascular changes elicited in conscious rabbits by stressful stimuli (loud sound, cage move, pinprick, formaldehyde vapour and air-jet stress). CP-154,526 substantially reduced pressor and heart rate responses to these stimuli (both vagally and sympathetically mediated), and reduced QT shortening during air-jet stress. Blocking of central CRF1 receptors attenuates cardiovascular responses to environmental stimuli, presumably by affecting brain centres that control cardiovascular functions.
E Nalivaiko; W W Blessing
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  1017     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-20     Completed Date:  2004-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  234-7     Citation Subset:  IM    
Department of Physiology, Centre for Neuroscience, Flinders University, Australia.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Blood Pressure / drug effects*
Electroencephalography / methods
Heart Rate / drug effects*
Propranolol / pharmacology
Pyrimidines / pharmacology*
Pyrroles / pharmacology*
Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*,  physiology
Stress, Psychological / physiopathology*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/CP 154526; 0/Pyrimidines; 0/Pyrroles; 0/Receptors, Corticotropin-Releasing Hormone; 525-66-6/Propranolol

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