Document Detail


CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food.
MedLine Citation:
PMID:  23748225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Highly palatable foods and dieting are major contributing factors for the development of compulsive eating in obesity and eating disorders. We previously demonstrated that intermittent access to palatable food results in corticotropin-releasing factor-1 (CRF1) receptor antagonist-reversible behaviors, which include excessive palatable food intake, hypophagia of regular chow, and anxiety-like behavior. However, the brain areas mediating these effects are still unknown. Male Wistar rats were either fed chow continuously for 7 days/week (Chow/Chow group), or fed chow intermittently 5 days/week, followed by a sucrose, palatable diet 2 days/week (Chow/Palatable group). Following chronic diet alternation, the effects of microinfusing the CRF1 receptor antagonist R121919 (0, 0.5, 1.5 μg/side) in the central nucleus of the amygdala (CeA), the basolateral nucleus of the amygdala (BlA), or the bed nucleus of the stria terminalis (BNST) were evaluated on excessive intake of the palatable diet, chow hypophagia, and anxiety-like behavior. Furthermore, CRF immunostaining was evaluated in the brain of diet cycled rats. Intra-CeA R121919 blocked both excessive palatable food intake and anxiety-like behavior in Chow/Palatable rats, without affecting chow hypophagia. Conversely, intra-BlA R121919 reduced the chow hypophagia in Chow/Palatable rats, without affecting excessive palatable food intake or anxiety-like behavior. Intra-BNST treatment had no effect. The treatments did not modify the behavior of Chow/Chow rats. Immunohistochemistry revealed an increased number of CRF-positive cells in CeA--but not in BlA or BNST--of Chow/Palatable rats, during both withdrawal and renewed access to the palatable diet, compared with controls. These results provide functional evidence that the CRF-CRF1 receptor system in CeA and BlA has a differential role in mediating maladaptive behaviors resulting from palatable diet cycling.
Authors:
Attilio Iemolo; Angelo Blasio; Stephen A St Cyr; Fanny Jiang; Kenner C Rice; Valentina Sabino; Pietro Cottone
Related Documents :
3026855 - Opioid peptides and the control of feeding in sheep.
17691545 - Supplementation with groundnut haulms for sheep fattening in the west african sahel.
11745515 - Early dissolution of a morsellised impacted silicate-free bioactive glass in metaphysea...
16414195 - Biological, seasonal and environmental factors associated with pulex irritans infestati...
25474045 - Inactivation of listeria monocytogenes by disinfectants and bacteriophages in suspensio...
24569525 - Error in the honeybee waggle dance improves foraging flexibility.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2013-06-10
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  38     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-16     Completed Date:  2014-06-03     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  2456-66     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amygdala / drug effects*,  metabolism
Animals
Anxiety / chemically induced
Corticotropin-Releasing Hormone / analysis,  physiology*
Diet / adverse effects
Dietary Sucrose / administration & dosage
Eating / drug effects*
Male
Pyrimidines / administration & dosage,  pharmacology*
Rats
Rats, Wistar
Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*,  metabolism,  physiology
Septal Nuclei / drug effects
Grant Support
ID/Acronym/Agency:
DA023680/DA/NIDA NIH HHS; DA030425/DA/NIDA NIH HHS; MH091945/MH/NIMH NIH HHS; MH093650/MH/NIMH NIH HHS; R00 DA023680/DA/NIDA NIH HHS; R01 DA030425/DA/NIDA NIH HHS; R01 MH091945/MH/NIMH NIH HHS; R01 MH093650/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Sucrose; 0/Pyrimidines; 0/R 121919; 0/Receptors, Corticotropin-Releasing Hormone; 9015-71-8/Corticotropin-Releasing Hormone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Error correction in latent inhibition and its disruption by opioid receptor blockade with naloxone.
Next Document:  Administration of the Y2 receptor agonist PYY3-36 in mice induces multiple behavioral changes releva...