Document Detail

CREM: a master-switch governing male germ cells differentiation and apoptosis.
MedLine Citation:
PMID:  9813195     Owner:  NLM     Status:  MEDLINE    
Several endocrine and neuronal functions are governed by the cAMP-dependent signalling pathway. In eukaryotes, transcriptional regulation upon stimulation of the adenylyl cyclase signalling pathway is mediated by a family of cAMP-responsive nuclear factors. The CREM gene plays a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. CREM is highly expressed in postmeiotic cells upon a striking developmental switch regulated by the pituitary hormone FSH. CREM-mutant mice generated by homologous recombination reveal that spermatogenesis stops at the first step of spermiogenesis. Late spermatids are completely absent while there is a significant increase in apoptotic germ cells. A series of post-meiotic germ cell-specific genes are not expressed. Mutant male mice completely lack spermatozoa. This phenotype is reminiscent of cases of human infertility.
P Sassone-Corsi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  9     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  475-82     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Academic Press.
Institut de Génétique et de Biologie Mole@a3culaire et Cellulaire, Centre National de la Recherche Scientifique INSERM-ULP, 67404 Illkirch, Strasbourg, France.
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MeSH Terms
Apoptosis* / drug effects
Cell Differentiation / drug effects
Cyclic AMP Response Element Modulator
DNA-Binding Proteins / physiology*
Repressor Proteins / physiology
Spermatogenesis / drug effects,  genetics*,  physiology*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Repressor Proteins; 135844-64-3/Cyclic AMP Response Element Modulator

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