Document Detail


CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan.
MedLine Citation:
PMID:  22391042     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Eosinophils have recently been shown to participate in innate immune responses against mycobacteria. We have investigated whether Mycobacterium bovis BCG regulate the human eosinophil immune response. A negative correlation between mycobacteria internalization and eosinophil activation was observed. In addition, mannose-capped lipoarabinomannan from M. bovis BCG (ManLAM) failed to induce a significant release of eosinophil peroxidase and TNF-α. Noteworthy, ManLAM exhibited a potent inhibitory effect on eosinophil peroxidase release by TLR2-activated eosinophils involving the complement receptor-3 molecule and the phosphatidylinositol-3 kinase pathway. ManLAM, generally present in pathogenic mycobacteria, plays an important role in modulating eosinophil-dependent immune response.
Authors:
Virginie Driss; Emmanuel Hermann; Fanny Legrand; Sylvie Loiseau; Marie Delbeke; Laurent Kremer; Yann Guerardel; David Dombrowicz; Monique Capron
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-25
Journal Detail:
Title:  Immunology letters     Volume:  -     ISSN:  1879-0542     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Inserm, U547, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, 59019 Lille, France; Inserm U837, Institut de Recherché sur le Cancer de Lille, Université Lille 2, Lille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ictal high-gamma oscillation (60-99Hz) in intracranial electroencephalography and postoperative seiz...
Next Document:  Neonatal (+)-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2...