Document Detail


CR1 genotype and haplotype involvement in coronary artery disease: the pivotal role of hypertension and dyslipidemia.
MedLine Citation:
PMID:  19578791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and coronary syndromes. Atherosclerosis is a complex multifactorial disorder. Data indicate that the complement proteins play a crucial role in the link between inflammation and atherogenesis. Thus, there is evidence supporting the role of complement activation in atherogenesis. Complement receptor 1 (CR1) is a membrane protein found on different cells involved in various activities of the complement system. We demonstrated the possible involvement of CR1 in atherosclerosis studying the allele and genotype frequencies of the CR1 Pro1827Arg, CR1 His1208Arg exon 22 and int27 HindIII polymorphisms in a sample of patients with angiographically documented coronary artery disease (CAD) (n=550) and in healthy controls (n=380) matched for age, gender and ethnicity. Our data showed no significant deviations between the two groups with regard to either allele or genotype frequencies. After stratification according to risk factors, our analysis revealed a reduced frequency of the GG genotype of the Pro1827Arg polymorphism in patients with CAD and dyslipidemia vs the controls (p=0.031) and of the GG and LL genotypes in CAD patients with dyslipidemia vs CAD patients without dyslipidemia regarding the Pro1827Arg and CR1 HindIII intron 27 polymorphisms (GG, p=0.019; LL, p=0.184). We analyzed the haplotype frequencies of CR1. A decrease in CAD patients carrying the CAC haplotype compared to controls (p=0.043) and a decrease in the CAC haplotype in CAD patients with hypertension vs healthy controls (p=0.029) were demonstrated. Our data showed a possible involvement of CR1 gene polymorphisms in the predisposition to the development of this disease.
Authors:
Chiara Boiocchi; Michele Zorzetto; Ilaria Sbarsi; Alessandro Pirotta; Sandra Schirinzi; Colomba Falcone; Mariaclara Cuccia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  24     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
Affiliation:
CIRMC, University of Pavia, and Department of Cardiology, Istituto di Cura Città di Pavia University Hospital, 27100 Pavia, Italy. chiara.b@ipvgen.unipv.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Coronary Artery Disease / genetics*,  physiopathology
Dyslipidemias / physiopathology
Female
Gene Frequency
Genotype
Haplotypes*
Humans
Hypertension / physiopathology
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide*
Receptors, Complement 3b / genetics*
Chemical
Reg. No./Substance:
0/Receptors, Complement 3b

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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