| COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers. | |
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MedLine Citation:
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PMID: 16538539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclooxygenase (COX)-2 is an inducible enzyme linked to tumor growth and angiogenesis. Its expression occurs in a wide range of preneoplastic and neoplastic conditions in humans, including colon and breast carcinomas. We evaluated the role of COX-2 as a mediator of angiogenesis in feline and canine invasive carcinomas (IMCs) and its role as a prognostic indicator. COX-2 expression was assessed in neoplastic samples and healthy mammary glands by immunohistochemistry, and related to the following clinicopathological parameters: age, tumor size, histologic type, tumor grading, vessel invasion, estrogen (ER) and progesterone receptor (PR) status, Ki-67, HER-2 overexpression, microvessel density (MVD), VEGF expression and overall survival (OS). In both species, COX-2 immunoreactivity was not observed in healthy tissues, whereas 96% of feline and 100% of canine invasive carcinomas scored positive. In queens, COX-2 overexpression was significantly correlated to ER-negative status (p=0.04) and to increased PR (p=0.038) expression, and angiogenesis assessed by VEGF expression (p=0.002). In bitches an increased COX-2 expression was significantly correlated to HER-2 overexpression (p=0.013) and to tumor dedifferentiation (p=0.03). In both species increased levels of COX-2 were correlated to poorer prognosis (p=0.03 in dogs and p=0.002 in cats). COX-2 is expressed in mammary tissues during tumorigenesis and its expression is associated with a poorer prognosis in bitches and queens. The correlation of COX-2 expression and angiogenesis provides support for a potential role of COX-2 inhibitors for the prevention and the treatment of feline IMCs via their anti-angiogenic properties. In the canine species, moreover, COX-2 may be important for mediating HER-2 induced mammary tumors. |
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Authors:
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F Millanta; S Citi; D Della Santa; M Porciani; A Poli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-15 |
Journal Detail:
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Title: Breast cancer research and treatment Volume: 98 ISSN: 0167-6806 ISO Abbreviation: Breast Cancer Res. Treat. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-13 Completed Date: 2007-01-11 Revised Date: 2007-05-16 |
Medline Journal Info:
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Nlm Unique ID: 8111104 Medline TA: Breast Cancer Res Treat Country: Netherlands |
Other Details:
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Languages: eng Pagination: 115-20 Citation Subset: IM |
Affiliation:
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Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Pisa, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Cyclooxygenase 2 / biosynthesis* Dogs Female Gene Expression Regulation, Neoplastic* Immunohistochemistry Mammary Neoplasms, Animal / enzymology* Models, Statistical Neovascularization, Pathologic Prognosis Treatment Outcome Tumor Markers, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; EC 1.14.99.1/Cyclooxygenase 2 |
| Comments/Corrections | |
Comment In:
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Breast Cancer Res Treat. 2007 Jan;101(2):247
[PMID:
16838111
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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