| COS-l, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor. | |
MedLine Citation:
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PMID: 11270409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstituted strain of one of these histidine-kinase-encoding genes, COS-1, in C. albicans. Neither strain showed any growth defect in a number of liquid media nor increased resistance or sensitivity to a number of antifungal drugs. Importantly, we show that the COS-1 homozygous disruption strain had significantly reduced virulence in a systemic murine model of candidosis. Thus, COS-1 appears to be an in vivo virulence factor and may represent a novel target for the development of antifungal drugs. |
Authors:
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C P Selitrennikoff; L Alex; T K Miller; K V Clemons; M I Simon; D A Stevens |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Medical mycology Volume: 39 ISSN: 1369-3786 ISO Abbreviation: Med. Mycol. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-28 Completed Date: 2001-09-06 Revised Date: 2013-12-13 |
Medline Journal Info:
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Nlm Unique ID: 9815835 Medline TA: Med Mycol Country: England |
Other Details:
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Languages: eng Pagination: 69-74 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Candida albicans / enzymology*, genetics, pathogenicity Candidiasis / microbiology Disease Models, Animal Fungal Proteins / genetics, metabolism Genes, Fungal Humans Mice Protein Kinases / genetics*, physiology Signal Transduction Virulence / genetics |
| Grant Support | |
ID/Acronym/Agency:
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AI 19296/AI/NIAID NIH HHS; R01-AI 33354/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; EC 2.7.-/Protein Kinases; EC 2.7.3.-/protein-histidine kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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