Document Detail


COS-l, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor.
MedLine Citation:
PMID:  11270409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstituted strain of one of these histidine-kinase-encoding genes, COS-1, in C. albicans. Neither strain showed any growth defect in a number of liquid media nor increased resistance or sensitivity to a number of antifungal drugs. Importantly, we show that the COS-1 homozygous disruption strain had significantly reduced virulence in a systemic murine model of candidosis. Thus, COS-1 appears to be an in vivo virulence factor and may represent a novel target for the development of antifungal drugs.
Authors:
C P Selitrennikoff; L Alex; T K Miller; K V Clemons; M I Simon; D A Stevens
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical mycology     Volume:  39     ISSN:  1369-3786     ISO Abbreviation:  Med. Mycol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-28     Completed Date:  2001-09-06     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Candida albicans / enzymology*,  genetics,  pathogenicity
Candidiasis / microbiology
Disease Models, Animal
Fungal Proteins / genetics,  metabolism
Genes, Fungal
Humans
Mice
Protein Kinases / genetics*,  physiology
Signal Transduction
Virulence / genetics
Grant Support
ID/Acronym/Agency:
AI 19296/AI/NIAID NIH HHS; R01-AI 33354/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Fungal Proteins; EC 2.7.-/Protein Kinases; EC 2.7.3.-/protein-histidine kinase

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