Document Detail

COPDX: an update of guidelines for the management of chronic obstructive pulmonary disease with a review of recent evidence.
MedLine Citation:
PMID:  16584369     Owner:  NLM     Status:  MEDLINE    
Long-acting beta(2) agonists are an effective and convenient treatment for chronic obstructive pulmonary disease (COPD), but do not significantly improve lung function. The long-acting anticholinergic tiotropium, which can be taken once daily, decreases exertional dyspnoea and increases endurance by reducing hyperinflation. The role in COPD of the combination of a long-acting beta(2) agonist and a glucocorticoid in a single inhaler remains unclear. The minimum duration of an effective pulmonary rehabilitation program that includes exercise training is 6 weeks. Long-term treatment with inhaled glucocorticoids may reduce the rate of decline in lung function, but the effect is small. Aminophylline should no longer be routinely used in acute exacerbations of COPD. Non-invasive positive pressure ventilation (NPPV) reduces mortality and hospital stay in patients with acute hypercapnic ventilatory failure; it is also an effective weaning strategy for patients who require intubation. Further studies are required to clarify the role of NPPV in the long-term management of stable COPD.
Michael J Abramson; Alan J Crockett; Peter A Frith; Christine F McDonald
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  184     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  342-5     Citation Subset:  IM    
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC.
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MeSH Terms
Administration, Inhalation
Administration, Oral
Adrenergic beta-Agonists / administration & dosage
Asthma / diagnosis
Bronchodilator Agents / administration & dosage
Diagnosis, Differential
Drug Combinations
Evidence-Based Medicine / methods,  standards
Expectorants / therapeutic use
Glucocorticoids / administration & dosage
Practice Guidelines as Topic*
Pulmonary Disease, Chronic Obstructive / diagnosis*,  therapy*
Respiratory Function Tests
Risk Factors
Scopolamine Derivatives / administration & dosage
Social Support
Vaccination / standards
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Bronchodilator Agents; 0/Drug Combinations; 0/Expectorants; 0/Glucocorticoids; 0/Scopolamine Derivatives; 136310-93-5/tiotropium

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