| COPD and Air Travel: Oxygen Equipment and Preflight Titration of Supplemental Oxygen. | |
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MedLine Citation:
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PMID: 21071527 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Patients with COPD may need supplemental oxygen during air travel to avoid development of severe hypoxemia. The current study evaluated whether the hypoxia-altitude simulation test (HAST), in which patients breathe 15.1% oxygen simulating aircraft conditions, can be used to establish the optimal dose of supplemental oxygen. Also, the various types of oxygen-delivery equipment allowed for air travel were compared. METHODS: In a randomized crossover trial, 16 patients with COPD were exposed to alveolar hypoxia: in a hypobaric chamber (HC) at 2,438 m (8,000 ft) and with a HAST. During both tests, supplemental oxygen was given by nasal cannula (NC) with (1) continuous flow, (2) an oxygen-conserving device, and (3) a portable oxygen concentrator (POC). RESULTS: Pao(2) kPa (mm Hg) while in the HC and during the HAST with supplemental oxygen at 2 L/min (pulse setting 2) on devices 1 to 3 was (1) 8.6 ± 1.0 (65 ± 8) vs 12.5 ± 2.4 (94 ± 18) (P < .001), (2) 8.6 ± 1.6 (64 ± 12) vs 9.7 ± 1.5 (73 ± 11) (P < .001), and (3) 7.7 ± 0.9 (58 ± 7) vs 8.2 ± 1.1 (62 ± 8) (P= .003), respectively. CONCLUSIONS: The HAST may be used to identify patients needing supplemental oxygen during air travel. However, oxygen titration using an NC during a HAST causes accumulation of oxygen within the facemask and underestimates the oxygen dose required. When comparing the various types of oxygen-delivery equipment in an HC at 2,438 m (8,000 ft), compressed gaseous oxygen with continuous flow or with an oxygen-conserving device resulted in the same Pao(2), whereas a POC showed significantly lower Pao(2) values. Trial registry: ClinicalTrials.gov; No.: Identifier: NCT01019538; URL: clinicaltrials.gov. |
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Authors:
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Aina Akerø; Anne Edvardsen; Carl C Christensen; Jan O Owe; Morten Ryg; Ole H Skjønsberg |
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Publication Detail:
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Type: Journal Article Date: 2010-11-11 |
Journal Detail:
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Title: Chest Volume: 140 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 84-90 Citation Subset: AIM; IM |
Affiliation:
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Department of Pulmonary Medicine, Oslo University Hospital Ullevål, 0407 Oslo, Norway. aina.akero@medisin.uio.no. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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