Document Detail


COPD predicts mortality in HF: the Norwegian Heart Failure Registry.
MedLine Citation:
PMID:  20206897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and chronic heart failure (HF) are common clinical conditions that share tobacco as a risk factor. Our aim was to evaluate the prognostic impact of COPD on HF patients. METHODS AND RESULTS: The Norwegian Heart Failure Registry was used. The study included 4132 HF patients (COPD, n = 699) from 22 hospitals (mean follow-up, 13.3 months). COPD patients were older, more often smokers and diabetics, less often on beta-blockers and had a higher heart rate. They were more often in New York Heart Association (NYHA) Class III or IV (COPD, 63%; no COPD, 51%), although left ventricular ejection fraction (LVEF) distribution was similar. COPD independently predicted death (adjusted hazard ratio [HR], 1.188; 95% CI: 1.015 to 1.391; P = 0.03) along with age, creatinine, NYHA Class III/IV (HR, 1.464; 95% CI: 1.286 to 1.667) and diabetes. beta-blockers at baseline were associated with improved survival in patients with LVEF < or =40% independently of COPD. CONCLUSION: COPD is associated with a poorer survival in HF patients. COPD patients are overrated in terms of NYHA class in comparison with patients with similar LVEF. Nonetheless, NYHA class remains the strongest predictor of death in these patients.
Authors:
Jonathan De Blois; Serge Simard; Dan Atar; Stefan Agewall;
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-01-06
Journal Detail:
Title:  Journal of cardiac failure     Volume:  16     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Centre Hospitalier Affili? Universitaire de Qu?bec, Quebec, Canada. jonathan.deblois@med.ulaval.ca
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Aged
Aged, 80 and over
Analysis of Variance
Cause of Death*
Chi-Square Distribution
Comorbidity
Female
Heart Failure / diagnosis,  epidemiology*,  therapy
Humans
Kaplan-Meiers Estimate
Male
Multivariate Analysis
Norway
Predictive Value of Tests
Probability
Proportional Hazards Models
Pulmonary Disease, Chronic Obstructive / diagnosis,  epidemiology*,  therapy
Registries
Risk Assessment
Severity of Illness Index
Sex Distribution
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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