Document Detail


COP1b, an isoform of COP1 generated by alternative splicing, has a negative effect on COP1 function in regulating light-dependent seedling development in Arabidopsis.
MedLine Citation:
PMID:  9529519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
COP1 is a negative regulator of Arabidopsis light-dependent development. Mutation of the COP1 locus causes constitutive photomorphogenesis in the dark. Here, we report the identification of an isoform of the COP1 protein, named COP1b, which is generated by alternative splicing. COP1b has a 60-amino acid deletion in the WD-40 repeat domain relative to the full-length COP1. This splicing step is light-independent and takes place mostly in mature seeds and in germinating seedlings. Transgenic Arabidopsis plants that overexpress COP1b show a de-etiolated phenotype in the dark, with a short hypocotyl, open and developed cotyledons. The transgenic seedlings are adult-lethal. These phenotypes closely resemble that of severe cop-1 mutants, indicating that COP1b has a dominant negative effect on COP1 function.
Authors:
D X Zhou; Y J Kim; Y F Li; P Carol; R Mache
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular & general genetics : MGG     Volume:  257     ISSN:  0026-8925     ISO Abbreviation:  Mol. Gen. Genet.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-23     Completed Date:  1998-04-23     Revised Date:  2005-04-12    
Medline Journal Info:
Nlm Unique ID:  0125036     Medline TA:  Mol Gen Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  387-91     Citation Subset:  IM; S    
Affiliation:
Laboratoire de Génétique Moléculaire des Plantes, Université Joseph Fourier, Grenoble, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Arabidopsis / genetics*,  growth & development,  radiation effects
Arabidopsis Proteins*
Base Sequence
Carrier Proteins / genetics*,  physiology
Gene Expression Regulation, Plant / radiation effects
Germination / genetics*,  radiation effects
Light
Molecular Sequence Data
Morphogenesis / radiation effects
Phenotype
Plant Proteins / genetics*,  physiology
Plants, Genetically Modified
RNA Splicing*
Repressor Proteins / genetics*,  physiology
Ubiquitin-Protein Ligases*
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Carrier Proteins; 0/Plant Proteins; 0/Repressor Proteins; EC 6.3.2.19/COP1 protein, Arabidopsis; EC 6.3.2.19/Ubiquitin-Protein Ligases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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