Document Detail


COMparison of Platelet reactivity following prAsugrel and ticagrelor loading dose in ST-Segment elevation myocardial infarctION patients: The COMPASSION study.
MedLine Citation:
PMID:  25275609     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Prasugrel and ticagrelor are potent P2Y12-ADP receptor antagonists which are superior to clopidogrel in acute coronary syndromes. To date no clinical trial directly compared these two drugs. Platelet reactivity correlates with ischemic and bleeding events in patients undergoing percutaneous coronary intervention. Recent pharmacological studies have observed a delayed onset of action of these two drugs in ST-segment elevation myocardial infarction (STEMI). We provide the first adequately powered pharmacological study comparing PR following ticagrelor and prasugrel loading dose (LD) in STEMI patients when the maximal biological effect is reached. In the present study, ticagrelor was associated with a lower rate of high on-treatment PR compared to prasugrel.
Authors:
Marc Laine; Mélanie Gaubert; Corinne Frère; Michael Peyrol; Franck Thuny; Serge Yvorra; Virginie Chelini; Bruno Bultez; Stephane Luigi; Zair Mokrani; Jacques Bessereau; Richard Toesca; Anne Champenois; Françoise Dignat-George; Franck Paganelli; Laurent Bonello
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-2
Journal Detail:
Title:  Platelets     Volume:  -     ISSN:  1369-1635     ISO Abbreviation:  Platelets     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-2     Completed Date:  -     Revised Date:  2014-10-3    
Medline Journal Info:
Nlm Unique ID:  9208117     Medline TA:  Platelets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-3     Citation Subset:  -    
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