Document Detail


COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study.
MedLine Citation:
PMID:  19023276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Heavy drinking can cause chronic hypertension, possibly due to effects on the autonomic nervous system. Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity.
METHODS: We evaluated the association of COMT genotype at this locus with blood pressure (BP) in 839 alcohol-dependent individuals before and during participation in an alcoholism treatment trial. Hierarchical linear models were used to account for within-subject correlation on repeated BP measurements, and findings were adjusted for age, gender, ethnicity, alcohol use, body mass index, current smoking, hypertension history, and study site.
RESULTS: Relative to those with the val-val genotype, those with the met-met genotype had higher adjusted systolic (+4.9 mm Hg, P < 0.01) and diastolic (+3.2 mm Hg, P < 0.01) BP at baseline. Those with the val-met genotype did not significantly differ from the val-val genotype. Changes in BP between baseline and 4 weeks of alcohol treatment also differed by genotype. Relative to the val-val genotype, the met-met genotype had a greater reduction in adjusted systolic pressure (-3.9 mm Hg, P < 0.01) and diastolic pressure (-2.8 mm Hg, P < 0.01). Corresponding relative reductions for the val-met genotype were -2.2 mm Hg systolic (P = 0.070) and -1.5 mm Hg diastolic (P < 0.05).
CONCLUSION: Findings suggest that alcohol-induced BP elevation may be related to the effects of catecholamines and their genetically determined inactivation.
Authors:
Scott H Stewart; Gabor Oroszi; Patrick K Randall; Raymond F Anton
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2008-11-20
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-01-06     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / complications*,  enzymology,  therapy
Blood Pressure / physiology*
Catechol O-Methyltransferase / blood,  genetics*
DNA / genetics*
Female
Genotype
Humans
Hypertension / enzymology,  genetics*,  physiopathology
Male
Polymerase Chain Reaction
Risk Factors
Grant Support
ID/Acronym/Agency:
K05 AA017435/AA/NIAAA NIH HHS; K05 AA017435-01/AA/NIAAA NIH HHS; K05AA 017435/AA/NIAAA NIH HHS; K23 AA014188/AA/NIAAA NIH HHS; K23 AA014188-06/AA/NIAAA NIH HHS; K23AA 014188/AA/NIAAA NIH HHS; U10 AA011783/AA/NIAAA NIH HHS; U10 AA011783-08/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA; EC 2.1.1.6/Catechol O-Methyltransferase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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