| COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study. | |
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MedLine Citation:
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PMID: 19023276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Heavy drinking can cause chronic hypertension, possibly due to effects on the autonomic nervous system. Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. METHODS: We evaluated the association of COMT genotype at this locus with blood pressure (BP) in 839 alcohol-dependent individuals before and during participation in an alcoholism treatment trial. Hierarchical linear models were used to account for within-subject correlation on repeated BP measurements, and findings were adjusted for age, gender, ethnicity, alcohol use, body mass index, current smoking, hypertension history, and study site. RESULTS: Relative to those with the val-val genotype, those with the met-met genotype had higher adjusted systolic (+4.9 mm Hg, P < 0.01) and diastolic (+3.2 mm Hg, P < 0.01) BP at baseline. Those with the val-met genotype did not significantly differ from the val-val genotype. Changes in BP between baseline and 4 weeks of alcohol treatment also differed by genotype. Relative to the val-val genotype, the met-met genotype had a greater reduction in adjusted systolic pressure (-3.9 mm Hg, P < 0.01) and diastolic pressure (-2.8 mm Hg, P < 0.01). Corresponding relative reductions for the val-met genotype were -2.2 mm Hg systolic (P = 0.070) and -1.5 mm Hg diastolic (P < 0.05). CONCLUSION: Findings suggest that alcohol-induced BP elevation may be related to the effects of catecholamines and their genetically determined inactivation. |
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Authors:
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Scott H Stewart; Gabor Oroszi; Patrick K Randall; Raymond F Anton |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2008-11-20 |
Journal Detail:
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Title: American journal of hypertension Volume: 22 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-01-06 Revised Date: 2013-03-08 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 87-91 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina, USA. stewarsh@musc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholism / complications*, enzymology, therapy Blood Pressure / physiology* Catechol O-Methyltransferase / blood, genetics* DNA / genetics* Female Genotype Humans Hypertension / enzymology, genetics*, physiopathology Male Polymerase Chain Reaction Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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K05 AA017435/AA/NIAAA NIH HHS; K05 AA017435-01/AA/NIAAA NIH HHS; K05AA 017435/AA/NIAAA NIH HHS; K23 AA014188-06/AA/NIAAA NIH HHS; K23AA 014188/AA/NIAAA NIH HHS; U10 AA011783/AA/NIAAA NIH HHS; U10 AA011783-08/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA; EC 2.1.1.6/Catechol O-Methyltransferase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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