Document Detail


COGENT (COlorectal cancer GENeTics) revisited.
MedLine Citation:
PMID:  22294761     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.
Authors:
Richard S Houlston;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mutagenesis     Volume:  27     ISSN:  1464-3804     ISO Abbreviation:  Mutagenesis     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-01     Completed Date:  2012-05-17     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Colorectal Neoplasms / diagnosis,  genetics*
Genes, Neoplasm*
Genetic Predisposition to Disease*
Humans
Polymorphism, Genetic / genetics*
Grant Support
ID/Acronym/Agency:
06113/C/04/Z)//Wellcome Trust; 090532//Wellcome Trust; 12076//Cancer Research UK; MC_U127527198//Medical Research Council; //Canadian Institutes of Health Research; //Cancer Research UK
Investigator
Investigator/Affiliation:
Lauri A Aaltonen / ; Hermann Brenner / ; Stephan Buch / ; Harry Campbell / ; Angel Carracedo / ; Luis Carvajal-Carmona / ; Antoni Castells / ; Sergi Castellví-Bel / ; Jeremy P Cheadle / ; Peter Devilee / ; Malcolm Dunlop / ; Magdalena M Echeverry / ; Steven Gallinger / ; Antonella Galvan / ; Jochen Hampe / ; Kari Hemminki / ; Judy W C Ho / ; Robert M W Hofstra / ; Tom J Hudson / ; Iva Kirac / ; Markus M Lerch / ; Li Li / ; Annika Lindblom / ; Lara Lipton / ; Koichi Matsuda / ; Timothy S Maughan / ; Victor Moreno / ; Hans Morreau / ; Alessio Naccarati / ; Yusuke Nakamura / ; Paolo Peterlongo / ; Paul D Pharoah / ; Oliver Sieber / ; Paolo Radice / ; Clara Ruiz-Ponte / ; Clemens Schafmayer / ; Christian A Schmidt / ; Witigo von Schönfels / ; Stefan Schreiber / ; Rodney Scott / ; Pak Sham / ; Pavel Soucek / ; Albert Tenesa / ; Ian P M Tomlinson / ; Alejandro Velez / ; Cristna M Villanueva / ; Pavel Vodicka / ; Henry Vo lzke / ; Tom van Wezel / ; Juul T Wijnen / ; Brent Zanke /
Comments/Corrections

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