| COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. | |
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MedLine Citation:
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PMID: 18803296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apolipoprotein E (apoE) is the primary apolipoprotein synthesized in the brain in response to injury with known neuroprotective effects exerted through antioxidant, antiinflammatory, antiexcitotoxic, and neurotrophic mechanisms. We have previously demonstrated that COG1410, an apoE mimetic peptide, exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). As in TBI, ischemia-reperfusion injury is a component of acute stroke, which displays a pharmacogenetic association with the APOE4 gene. Using an intraluminal middle cerebral occlusion (MCAO) model in rats, we found that a single intravenous injection of COG1410 at 120 min post-MCAO significantly improved vestibulomotor function, decreased poststroke locomotor asymmetry, and decreased infarct volume of the ipsilateral hemisphere. These results support further exploration of a novel apoE-mimetic peptide, COG1410, as a therapeutic treatment for stroke. |
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Authors:
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Elena A Tukhovskaya; Alexey Yu Yukin; Oksana N Khokhlova; Arkady N Murashev; Michael P Vitek |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of neuroscience research Volume: 87 ISSN: 1097-4547 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-03 Completed Date: 2009-03-31 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
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Languages: eng Pagination: 677-82 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley-Liss, Inc. |
Affiliation:
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Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow Region, Russia. lenoktuk@rambler.ru |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoproteins E / administration & dosage, therapeutic use* Brain / blood supply, drug effects, pathology, physiopathology Disease Models, Animal Infarction, Middle Cerebral Artery / drug therapy*, physiopathology Ketamine / pharmacology Male Motor Activity / drug effects* Postural Balance / drug effects* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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AG 020473/AG/NIA NIH HHS; R44 AG020473-05/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/COG1410; 6740-88-1/Ketamine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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