| CO2 elimination at varying inspiratory pause in acute lung injury. | |
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MedLine Citation:
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PMID: 17204030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have indicated that, during mechanical ventilation, an inspiratory pause enhances gas exchange. This has been attributed to prolonged time during which fresh gas of the tidal volume is present in the respiratory zone and is available for distribution in the lung periphery. The mean distribution time of inspired gas (MDT) is the mean time during which fractions of fresh gas are present in the respiratory zone. All ventilators allow setting of pause time, T(P), which is a determinant of MDT. The objective of the present study was to test in patients the hypothesis that the volume of CO(2) eliminated per breath, V(T)CO(2), is correlated to the logarithm of MDT as previously found in animal models. Eleven patients with acute lung injury were studied. When T(P) increased from 0% to 30%, MDT increased fourfold. A change of T(P) from 10% to 0% reduced V(T)CO(2) by 14%, while a change to 30% increased V(T)CO(2) by 19%. The relationship between V(T)CO(2) and MDT was in accordance with the logarithmic hypothesis. The change in V(T)CO(2) reflected to equal extent changes in airway dead space and alveolar PCO(2) read from the alveolar plateau of the single breath test for CO(2). By varying T(P), effects are observed on V(T)CO(2), airway dead space and alveolar PCO(2). These effects depend on perfusion, gas distribution and diffusion in the lung periphery, which need to be further elucidated. |
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Authors:
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J Aboab; L Niklason; L Uttman; A Kouatchet; L Brochard; B Jonson |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 27 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-05 Completed Date: 2007-03-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 2-6 Citation Subset: IM |
Affiliation:
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Medical Intensive Care Unit, INSERM U492, Hôpital H. Mondor, Créteil, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carbon Dioxide / metabolism* Female Humans Inhalation* Male Middle Aged Pulmonary Gas Exchange* Respiration, Artificial* Respiratory Dead Space* Respiratory Distress Syndrome, Adult / physiopathology*, therapy* Respiratory Mechanics* |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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