Document Detail

CO2 chemosensitivity during immersion in humans.
MedLine Citation:
PMID:  8549236     Owner:  NLM     Status:  MEDLINE    
Hypercapnic ventilatory response was compared in 9 seated subjects during head-out immersion in 35 degrees C (thermoneutral) water and during non-immersion in 28 degrees C (thermoneutral) room air. Using Read's CO2-rebreathing technique, minute ventilation (VE) and end-tidal (ET) PCO2 were sampled continuously for 4-5 min with a spirometer and a mass spectrometer, while the subject rebreathed a 6 L gas mixture initially containing 7% CO2 and 93% O2 in a bag-in-box system. The slope of the hypercapnic ventilatory response curve, expressed as delta VE/delta PETCO2, ranged from 0.76 to 2.49 L/min/mmHg. Immersion affected neither the slope nor the position of the hypercapnic ventilatory response curve. The rate of rise of PETCO2 during immersed CO2-rebreathing was significantly reduced (4.47 +/- 0.19 [SE] mmHg/min), as compared to the control value (5.67 +/- 0.24). It was concluded that the CO2 chemosensitivity during immersion in humans did not change and that the capacity to store CO2 in tissue might have been increased.
L P Chang; C E Lundgren
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Chinese journal of physiology     Volume:  38     ISSN:  0304-4920     ISO Abbreviation:  Chin J Physiol     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-20     Completed Date:  1996-02-20     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  7804502     Medline TA:  Chin J Physiol     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Department of Hyperbaric and Diving Medicine, Naval General Hospital, Tsoying, Taiwan, R.O.C.
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MeSH Terms
Administration, Inhalation
Carbon Dioxide / blood,  metabolism,  pharmacology*
Mass Spectrometry
Partial Pressure
Respiration / drug effects
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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