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CO(2) Laser therapy versus cryotherapy in treatment of genital warts; a Randomized Controlled Trial (RCT).
MedLine Citation:
PMID:  23205250     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Genital warts, due to specific types of the human papillomavirus, have long been regarded as one of the most important causes of cervical cancer and one of the most common cause of Sexually Transmited Diseases (STDs). Over the years, it has been the focus of several studies in order to find the best effective approach to eradicate the virus, however there are still controversies regarding this matter. We compared efficacy of the two physical ablative therapies; Liquid Nitrogen and CO(2) laser.
MATERIAL AND METHODS: One hundred and sixty patients, with external genital warts, were divided into two groups. Each group consisted of 80 patients treated with CO(2)-laser or cryotherapy. Clearance and recurrence rates were evaluated for 3 months.
RESULTS: Complete clearance was achieved in 76 lesions (95%) treated by CO(2)-laser and 37 lesions (46.2%) treated by cryotherapy which was significantly different (p < 0.001). In the CO(2)-laser group, lesions required only one treatment to clear while in the cryotherapy group, lesions required two (12%) even up to three (12.2%) treatments for some patients to clear completely. Laser therapy was associated with less recurrence rate compared to cryotherapy (0.05% Vs 0.18%).
CONCLUSION: Generally, the efficacy of CO(2) laser treatment of external genital warts was approximately two fold greater than cryotherapy and it was associated with lower recurrence rate.
Authors:
M Azizjalali; Gh Ghaffarpour; B Mousavifard
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of microbiology     Volume:  4     ISSN:  2008-4447     ISO Abbreviation:  Iran J Microbiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2012-12-12     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101518404     Medline TA:  Iran J Microbiol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  -    
Affiliation:
Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Dermatology, Rasoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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